PDF(Pubmed)
Abstract：
Nickel and cobalt are frequently found in metallic alloys used in the manufacture of aneurysm clips and endovascular prostheses, such as the pipeline embolization device (PED). Nickel hypersensitivity can affect up to 15% of the population, however, it is very rarely overt in patients who undergo endovascular stent placement. Here, we present the case of a 35-year-old woman who developed allergic symptoms after PED placement and was later confirmed to be allergic to both nickel and cobalt by patch testing. Fortunately, she responded well to pharmacologic treatment, rendering surgical intervention unnecessary. To the best of our knowledge, this is the first report of symptomatic nickel hypersensitivity, and the second report of symptomatic cobalt allergy caused by the PED. Despite its low prevalence, we believe that surgeons should actively inquire patients in the postoperative period about allergic symptoms, to facilitate early diagnosis and treatment.
摘要：
镍和钴通常存在于用于制造动脉瘤夹和血管内假体的金属合金中，如管道栓塞装置(PED)。镍超敏反应可以影响高达15％的人口，然而,在接受血管内支架置入术的患者中，这种情况很少明显。这里,我们介绍了一例35岁女性,她在PED置入后出现过敏症状,后来通过斑贴试验证实对镍和钴均过敏.幸运的是,她对药物治疗反应良好,不需要手术干预。据我们所知,这是首次报告有症状的镍超敏反应,和第二次报告由PED引起的有症状的钴过敏。尽管患病率低，我们认为外科医生应该在术后积极询问患者过敏症状，便于早期诊断和治疗。
