PDF(Pubmed)
Abstract：
Atrial fibrillation (AF) is a common arrhythmia requiring effective heart rate (HR) management. Conventional therapies may not always achieve the desired HR control during intraoperative conditions. We present two cases of AF patients in whom dexmedetomidine, an alpha-2 receptor agonist, was utilized during surgery when conventional treatments proved ineffective. In Case 1, a 65-year-old male with multiple comorbidities underwent surgery. Despite receiving intraoperative medications for AF, his HR remained uncontrolled. Dexmedetomidine successfully stabilized his HR without complications. In Case 2, a 75-year-old male with heart disease experienced a sudden HR surge during surgery, which remained uncontrolled despite conventional treatment. Dexmedetomidine effectively managed his HR, ensuring a safer surgical course. While the primary indication of dexmedetomidine is not arrhythmia management, this case report suggests its potential in challenging cases. Further research is needed to explore its therapeutic role in tachyarrhythmia management and establish appropriate dosing strategies.
摘要：
心房颤动（AF）是一种常见的心律失常，需要有效的心率（HR）管理。在术中状况期间,常规疗法可能不总是实现期望的HR控制。我们介绍了两例房颤患者，其中右美托咪定，α-2受体激动剂,当常规治疗被证明无效时，在手术过程中使用。在病例1中，一名患有多种合并症的65岁男性接受了手术。尽管接受了房颤术中药物治疗，他的HR仍然不受控制。右美托咪定成功稳定HR，无并发症。在案例2中，一名患有心脏病的75岁男性在手术过程中突然出现HR激增，尽管进行了常规治疗，但仍不受控制。右美托咪定有效地管理了他的HR,确保手术过程更安全。虽然右美托咪定的主要适应症不是心律失常管理，本病例报告显示了其在挑战性病例中的潜力。需要进一步的研究来探索其在快速性心律失常管理中的治疗作用并建立适当的给药策略。
