PDF(Pubmed)
Abstract：
UNASSIGNED: The association between benign paroxysmal positional vertigo (BPPV) and various mental disorders is still controversial. This study used the Mendelian randomization (MR) method to clarify the correlation between BPPV and seven mental disorders (bipolar disorder, depression, anxiety disorder, schizophrenia, suicidality, neuroticism, and mood swings) to aid in the exploration of BPPV complications and prevention and early treatment of mental disorders.
UNASSIGNED: The datasets for BPPV and seven mental disorders were obtained from genome-wide association studies (GWASs). Two-sample MR was used to analyze the correlation between exposure (BPPV) and various outcomes (bipolar disorder, depression, anxiety disorder, schizophrenia, suicidality, neuroticism, and mood swings). A reverse MR study was also performed. The inverse variance weighting (IVW) method, the MR-Egger method, the simple mode method, the weighted mode method, and the weighted median method were selected.
UNASSIGNED: The MR analysis and the reverse MR analysis results did not reveal significant associations between BPPV and bipolar disorder, depression, anxiety disorder, schizophrenia, suicidal tendencies, neuroticism, and mood swings. Interestingly, neuroticism (IVW: OR = 1.142, 95% CI: 1.059-1.231, P = 0.001; P-MR-PRESSO adjustment = 0.0002) and mood swings (IVW: OR = 3.119, 95% CI: 1.652-5.884, P = 0.0004) may have a significant association with BPPV. After MR-PRESSO adjustment, there was no horizontal pleiotropy or heterogeneity, and a significant association between neuroticism, mood swings, and BPPV has still been suggested.
UNASSIGNED: We conducted MR analysis on genetic data from European populations and discovered a causal relationship between BPPV and the seven mental disorders. Our research findings suggest that BPPV may not have a significant causal relationship with bipolar disorder, depression, anxiety disorder, schizophrenia, or suicidal tendencies. However, neuroticism and mood swings may be risk factors for BPPV.
UNASSIGNED: The datasets for BPPV and seven mental disorders were obtained from genome-wide association studies (GWASs). Two-sample MR was used to analyze the correlation between exposure (BPPV) and various outcomes (bipolar disorder, depression, anxiety disorder, schizophrenia, suicidality, neuroticism, and mood swings). A reverse MR study was also performed. The inverse variance weighting (IVW) method, the MR-Egger method, the simple mode method, the weighted mode method, and the weighted median method were selected.
UNASSIGNED: The MR analysis and the reverse MR analysis results did not reveal significant associations between BPPV and bipolar disorder, depression, anxiety disorder, schizophrenia, suicidal tendencies, neuroticism, and mood swings. Interestingly, neuroticism (IVW: OR = 1.142, 95% CI: 1.059-1.231, P = 0.001; P-MR-PRESSO adjustment = 0.0002) and mood swings (IVW: OR = 3.119, 95% CI: 1.652-5.884, P = 0.0004) may have a significant association with BPPV. After MR-PRESSO adjustment, there was no horizontal pleiotropy or heterogeneity, and a significant association between neuroticism, mood swings, and BPPV has still been suggested.
UNASSIGNED: We conducted MR analysis on genetic data from European populations and discovered a causal relationship between BPPV and the seven mental disorders. Our research findings suggest that BPPV may not have a significant causal relationship with bipolar disorder, depression, anxiety disorder, schizophrenia, or suicidal tendencies. However, neuroticism and mood swings may be risk factors for BPPV.
摘要：
■良性阵发性位置性眩晕（BPPV）与各种精神障碍之间的关联仍然存在争议。本研究使用孟德尔随机化（MR）方法来阐明BPPV与7种精神障碍（双相情感障碍，抑郁症,焦虑症,精神分裂症,自杀,神经质,和情绪波动），以帮助探索BPPV并发症以及预防和早期治疗精神障碍。
■BPPV和7种精神障碍的数据集从全基因组关联研究（GWAS）获得。双样本MR用于分析暴露（BPPV）与各种结局（双相情感障碍，抑郁症,焦虑症,精神分裂症,自杀,神经质,和情绪波动）。还进行了反向MR研究。方差逆加权(IVW)方法，MR-Egger方法，简单模式方法，加权模式法，并选用加权中位数法。
■MR分析和反向MR分析结果未揭示BPPV和双相情感障碍之间的显著关联，抑郁症,焦虑症,精神分裂症,自杀倾向,神经质,和情绪波动。有趣的是,神经质(IVW:OR=1.142,95%CI:1.059-1.231,P=0.001;P-MR-PRESSO调整=0.0002)和情绪波动(IVW:OR=3.119,95%CI:1.652-5.884,P=0.0004)可能与BPPV有显著关联。MR-PRESSO调整后,没有水平多效性或异质性，和神经质之间的显著关联，情绪波动,和BPPV仍然被建议。
■我们对来自欧洲人群的遗传数据进行了MR分析，发现了BPPV与七种精神障碍之间的因果关系。我们的研究结果表明，BPPV可能与双相情感障碍没有显著的因果关系，抑郁症,焦虑症,精神分裂症,或者自杀倾向.然而,神经质和情绪波动可能是BPPV的危险因素。
■BPPV和7种精神障碍的数据集从全基因组关联研究（GWAS）获得。双样本MR用于分析暴露（BPPV）与各种结局（双相情感障碍，抑郁症,焦虑症,精神分裂症,自杀,神经质,和情绪波动）。还进行了反向MR研究。方差逆加权(IVW)方法，MR-Egger方法，简单模式方法，加权模式法，并选用加权中位数法。
■MR分析和反向MR分析结果未揭示BPPV和双相情感障碍之间的显著关联，抑郁症,焦虑症,精神分裂症,自杀倾向,神经质,和情绪波动。有趣的是,神经质(IVW:OR=1.142,95%CI:1.059-1.231,P=0.001;P-MR-PRESSO调整=0.0002)和情绪波动(IVW:OR=3.119,95%CI:1.652-5.884,P=0.0004)可能与BPPV有显著关联。MR-PRESSO调整后,没有水平多效性或异质性，和神经质之间的显著关联，情绪波动,和BPPV仍然被建议。
■我们对来自欧洲人群的遗传数据进行了MR分析，发现了BPPV与七种精神障碍之间的因果关系。我们的研究结果表明，BPPV可能与双相情感障碍没有显著的因果关系，抑郁症,焦虑症,精神分裂症,或者自杀倾向.然而,神经质和情绪波动可能是BPPV的危险因素。
