PDF(Pubmed)
Abstract：
The limited literature and increasing interest in studies on cardiac electrophysiology, explicitly focusing on cardiac ion channelopathies and sudden cardiac death in diverse populations, has prompted a comprehensive examination of existing research. Our review specifically targets Hispanic/Latino and Indigenous populations, which are often underrepresented in healthcare studies. This review encompasses investigations into genetic variants, epidemiology, etiologies, and clinical risk factors associated with arrhythmias in these demographic groups. The review explores the Hispanic paradox, a phenomenon linking healthcare outcomes to socioeconomic factors within Hispanic communities in the United States. Furthermore, it discusses studies exemplifying this observation in the context of arrhythmias and ion channelopathies in Hispanic populations. Current research also sheds light on disparities in overall healthcare quality in Indigenous populations. The available yet limited literature underscores the pressing need for more extensive and comprehensive research on cardiac ion channelopathies in Hispanic/Latino and Indigenous populations. Specifically, additional studies are essential to fully characterize pathogenic genetic variants, identify population-specific risk factors, and address health disparities to enhance the detection, prevention, and management of arrhythmias and sudden cardiac death in these demographic groups.
摘要：
有限的文献和对心脏电生理学研究的兴趣日益增加，明确关注不同人群的心脏离子通道病和心源性猝死，促使对现有研究进行全面审查。我们的审查专门针对西班牙裔/拉丁裔和土著居民，在医疗保健研究中往往代表性不足。这篇综述包括对遗传变异的调查，流行病学,病因，以及这些人口统计学人群中与心律失常相关的临床危险因素。这篇评论探讨了西班牙裔悖论，美国西班牙裔社区内将医疗保健结果与社会经济因素联系起来的现象。此外，它讨论了在西班牙裔人群中心律失常和离子通道病的背景下证明这一观察结果的研究。目前的研究还揭示了土著居民整体医疗质量的差异。现有但有限的文献强调，迫切需要对西班牙裔/拉丁裔和土著居民的心脏离子通道病进行更广泛和全面的研究。具体来说,额外的研究对于充分表征致病性遗传变异至关重要，确定特定人群的风险因素，并解决健康差异以加强检测，预防,以及这些人口统计学人群中心律失常和心源性猝死的管理。
