PDF(Pubmed)
Abstract：
OBJECTIVE: The objective of this study is to determine the relationship between serum vitamin D level and the risk of developing benign paroxysmal positional vertigo (BPPV) incidence and recurrence in countries in the Northern Hemisphere.
METHODS: Systematic review and meta-analysis.
METHODS: PubMed, Scopus and Web of Science databases were searched for studies published between January 2000 and February 2023.
METHODS: Participants located in the Northern Hemisphere aged 18 or over with at least one episode of BPPV, serum 25-hydroxyvitamin D levels measured and reported, no comorbidities or history of vitamin D supplementation.
METHODS: Data extraction and synthesis were performed by a single reviewer and checked by a second reviewer. Inclusion and exclusion criteria and risk of bias were assessed by two independent reviewers using the Newcastle Ottawa Tool for Cohort studies and Risk of Bias Assessment Tool for Nonrandomised Studies checklist for case-control studies. Meta-analysis was conducted using random effects models. Standard mean difference with a 95% CI was used to measure the relationship between vitamin D level and BPPV.
RESULTS: The 35 articles identified by the literature search reported data of 9843 individuals. 19 studies (7387 individuals) were included in the BPPV incidence meta-analysis while 7 studies (622 individuals) were included in the BPPV recurrence meta-analysis. Lower serum vitamin D levels were found in BPPV incidence compared with controls, but the relationship between vitamin D levels in recurrent BPPV compared with non-recurrent disease remained uncertain.
CONCLUSIONS: Results of this systematic review and meta-analysis demonstrated a negative correlation between serum vitamin D and BPPV incidence, while any relationship between serum vitamin D and BPPV recurrence remained uncertain. Risk of bias analysis revealed evidence of variable quality. There were insufficient data available to evaluate seasonal relationships between serum vitamin D and BPPV. Given the potential for this as a confounding factor, future research should aim to investigate this further.
UNASSIGNED: CRD42021271840.
METHODS: Systematic review and meta-analysis.
METHODS: PubMed, Scopus and Web of Science databases were searched for studies published between January 2000 and February 2023.
METHODS: Participants located in the Northern Hemisphere aged 18 or over with at least one episode of BPPV, serum 25-hydroxyvitamin D levels measured and reported, no comorbidities or history of vitamin D supplementation.
METHODS: Data extraction and synthesis were performed by a single reviewer and checked by a second reviewer. Inclusion and exclusion criteria and risk of bias were assessed by two independent reviewers using the Newcastle Ottawa Tool for Cohort studies and Risk of Bias Assessment Tool for Nonrandomised Studies checklist for case-control studies. Meta-analysis was conducted using random effects models. Standard mean difference with a 95% CI was used to measure the relationship between vitamin D level and BPPV.
RESULTS: The 35 articles identified by the literature search reported data of 9843 individuals. 19 studies (7387 individuals) were included in the BPPV incidence meta-analysis while 7 studies (622 individuals) were included in the BPPV recurrence meta-analysis. Lower serum vitamin D levels were found in BPPV incidence compared with controls, but the relationship between vitamin D levels in recurrent BPPV compared with non-recurrent disease remained uncertain.
CONCLUSIONS: Results of this systematic review and meta-analysis demonstrated a negative correlation between serum vitamin D and BPPV incidence, while any relationship between serum vitamin D and BPPV recurrence remained uncertain. Risk of bias analysis revealed evidence of variable quality. There were insufficient data available to evaluate seasonal relationships between serum vitamin D and BPPV. Given the potential for this as a confounding factor, future research should aim to investigate this further.
UNASSIGNED: CRD42021271840.
摘要：
目的：本研究的目的是确定血清维生素D水平与北半球国家发生良性阵发性位置性眩晕（BPPV）发病率和复发风险之间的关系。
方法：系统评价和荟萃分析。
方法：PubMed，搜索了Scopus和WebofScience数据库，以查找2000年1月至2023年2月之间发表的研究。
方法：位于北半球18岁或以上且至少有一次BPPV发作的参与者，测量和报告血清25-羟基维生素D水平，没有合并症或补充维生素D的历史。
方法：数据提取和合成由单个审阅者进行，并由第二个审阅者进行检查。纳入和排除标准以及偏倚风险由两名独立的审核员使用纽卡斯尔渥太华队列研究工具和非随机研究偏倚风险评估工具清单进行病例对照研究评估。采用随机效应模型进行Meta分析。使用95%CI的标准平均差来测量维生素D水平与BPPV之间的关系。
结果：通过文献检索确定的35篇文章报道了9843名个体的数据。19项研究（7387例）纳入BPPV发病率荟萃分析，7项研究（622例）纳入BPPV复发荟萃分析。与对照组相比，在BPPV发病率中发现血清维生素D水平较低，但复发性BPPV与非复发性疾病中维生素D水平之间的关系仍不确定.
结论：本系统综述和荟萃分析的结果表明，血清维生素D与BPPV发病率呈负相关，而血清维生素D与BPPV复发之间的任何关系仍不确定。偏倚风险分析揭示了质量可变的证据。没有足够的数据来评估血清维生素D和BPPV之间的季节性关系。考虑到这可能是一个混杂因素，未来的研究应该旨在进一步调查这一点。
■CRD42021271840。
方法：系统评价和荟萃分析。
方法：PubMed，搜索了Scopus和WebofScience数据库，以查找2000年1月至2023年2月之间发表的研究。
方法：位于北半球18岁或以上且至少有一次BPPV发作的参与者，测量和报告血清25-羟基维生素D水平，没有合并症或补充维生素D的历史。
方法：数据提取和合成由单个审阅者进行，并由第二个审阅者进行检查。纳入和排除标准以及偏倚风险由两名独立的审核员使用纽卡斯尔渥太华队列研究工具和非随机研究偏倚风险评估工具清单进行病例对照研究评估。采用随机效应模型进行Meta分析。使用95%CI的标准平均差来测量维生素D水平与BPPV之间的关系。
结果：通过文献检索确定的35篇文章报道了9843名个体的数据。19项研究（7387例）纳入BPPV发病率荟萃分析，7项研究（622例）纳入BPPV复发荟萃分析。与对照组相比，在BPPV发病率中发现血清维生素D水平较低，但复发性BPPV与非复发性疾病中维生素D水平之间的关系仍不确定.
结论：本系统综述和荟萃分析的结果表明，血清维生素D与BPPV发病率呈负相关，而血清维生素D与BPPV复发之间的任何关系仍不确定。偏倚风险分析揭示了质量可变的证据。没有足够的数据来评估血清维生素D和BPPV之间的季节性关系。考虑到这可能是一个混杂因素，未来的研究应该旨在进一步调查这一点。
■CRD42021271840。
