Abstract：
There is a growing interest in the role of the miRNA family in human cancer. The miRNA-192 family is a group of conserved small RNAs, including miR-192, miR-194, and miR-215. Recent studies have shown that the incidence and mortality of breast cancer have been increasing epidemiologically year by year, and it is urgent to clarify the pathogenesis of breast cancer and seek new diagnostic and therapeutic methods. There is increasing evidence that miR-192 family members may be involved in the occurrence and development of breast cancer. This review describes the regulatory mechanism of the miRNA-192 family affecting the malignant behavior of breast cancer cells and evaluates the value of the miRNA-192 family as a diagnostic and prognostic biomarker for breast cancer. It is expected that summarizing and discussing the relationship between miRNA-192 family members and breast cancer, it will provide a new direction for the clinical diagnosis and treatment of breast cancer and basic medical research.
摘要：
人们对miRNA家族在人类癌症中的作用越来越感兴趣。miRNA-192家族是一组保守的小RNA,包括miR-192、miR-194和miR-215。最近的研究表明,乳腺癌的发病率和死亡率在流行病学上呈逐年上升趋势,阐明乳腺癌的发病机制,寻求新的诊断和治疗方法已迫在眉睫。越来越多的证据表明miR-192家族成员可能参与乳腺癌的发生发展。本文综述了miRNA-192家族影响乳腺癌细胞恶性行为的调控机制,并评价了miRNA-192家族作为乳腺癌诊断和预后标志物的价值。希望对miRNA-192家族成员与乳腺癌的关系进行总结和探讨,为乳腺癌的临床诊治和基础医学研究提供了新的方向。
