PDF(Pubmed)
Abstract：
Diabetic retinopathy (DR) is a complication of diabetes with a complex pathophysiology and multiple factors involved. Recently, it has been found that the upregulation of the renin-angiotensin-aldosterone system (RAAS) leads to overexpression of angiotensin II (Ang II), which induces oxidative stress, inflammation, and angiogenesis in the retina. Therefore, RAAS may be a promising therapeutic target in DR. Notably, RAAS inhibitors are often used in the treatment of hypertension. Still, the potential role and mechanism of DR must be further studied. In this review, we discuss and summarize the pathology and potential therapeutic goals of RAAS in DR.
摘要：
糖尿病视网膜病变（DR）是糖尿病的一种并发症，其病理生理复杂，涉及多种因素。最近,已经发现，肾素-血管紧张素-醛固酮系统（RAAS）的上调导致血管紧张素II（AngII）的过表达，诱导氧化应激，炎症,和视网膜中的血管生成。因此,RAAS可能是DR中一个有希望的治疗靶点。值得注意的是,RAAS抑制剂通常用于治疗高血压。尽管如此，DR的潜在作用和机制有待进一步研究。在这次审查中,我们讨论并总结了DR中RAAS的病理学和潜在的治疗目标。
