Abstract：
Herein, an aqueous phase synthesis approach was presented for the fabrication of copper nanoclusters (Cu NCs) with aggregation-induced emission (AIE) property, utilizing lipoic acid and NaBH4 as ligands and reducing agent, respectively. The as-synthesized Cu NCs exhibit an average size of 3.0 ± 0.2 nm and demonstrate strong solid-state fluorescence upon excitation with UV light. However, when dissolved in water, no observable fluorescent emission is detected in the aqueous solution of Cu NCs. Remarkably, the addition of Methimazole induced a significant red fluorescence from the aqueous solution of Cu NCs. This unexpected phenomenon can be ascribed to the aggregation of negatively charged Cu NCs caused by electrostatic interaction with positively charged imidazole groups in Methimazole, resulting in enhanced fluorescence through AIE mechanism. Therefore, there exists an excellent linear correlation between the fluorescent intensities of Cu NCs aqueous solution and the concentration of Methimazole within a range of 0.1-1.5 mM with a low limit of detection of 82.2 µM. Importantly, the designed enhanced-fluorescent nanoprobe based on Cu NCs exhibits satisfactory performance in assaying commercially available Methimazole tablets, demonstrating its exceptional sensitivity, reliability, and accuracy.
摘要：
在这里，提出了一种水相合成方法，用于制备具有聚集诱导发射（AIE）性质的铜纳米簇（CuNC），利用硫辛酸和NaBH4作为配体和还原剂，分别。合成后的CuNC的平均尺寸为3.0±0.2nm，并在紫外光激发下显示出强的固态荧光。然而,当溶解在水中时，在CuNCs的水溶液中没有检测到可观察到的荧光发射。值得注意的是,甲基咪唑的添加从CuNCs的水溶液中诱导出显著的红色荧光。这种意想不到的现象可以归因于与甲基咪唑中带正电荷的咪唑基团的静电相互作用引起的带负电荷的CuNCs的聚集，通过AIE机制导致荧光增强。因此,在0.1-1.5mM的范围内，CuNCs水溶液的荧光强度与甲基咪唑的浓度之间存在极好的线性相关性，低检测限为82.2µM。重要的是,所设计的基于CuNCs的增强荧光纳米探针在测定市售甲基咪唑片剂方面表现出令人满意的性能，展示了其非凡的敏感性，可靠性,和准确性。
