PDF(Pubmed)
Abstract：
The goal of this meta-analysis was to study nasal nitric oxide (nNO) measurements in allergic rhinitis (AR) and non-allergic rhinitis (non-AR). The protocol was registered with PROSPERO (no: CRD4202124828). Electronic databases from PubMed, Google Scholar, Scopus, Web of Science, and Cochrane were all thoroughly searched and studies were chosen based on the qualifying requirements. The quality of the studies was evaluated by Joanna Briggs Institute evaluation tools, and publication bias using funnel plots. The meta-analysis included 18 studies, whereas the systematic review included 20 studies, totaling 3097 participants (1581 AR, 458 non-AR, and 1058 healthy/control). Patients with AR had significantly greater nNO levels than the control group, although this did not change significantly before or after treatment. AR patients had significantly greater nNO levels than non-AR patients, but there was no significant difference between non-AR patients and healthy controls. Nineteen of the studies were of high quality and the remaining one was of moderate quality. nNO measurement has a promising role in the management of AR and non-AR patients, but more investigations are needed to document clinical benefits.
摘要：
这项荟萃分析的目的是研究过敏性鼻炎（AR）和非过敏性鼻炎（非AR）的鼻一氧化氮（nNO）测量。该方案已在PROSPERO注册（编号：CRD4202124828）。PubMed的电子数据库，谷歌学者，Scopus,WebofScience,对Cochrane和Cochrane都进行了彻底的搜索，并根据合格要求选择了研究。研究的质量由乔安娜·布里格斯研究所的评估工具进行评估，和使用漏斗图的出版偏倚。荟萃分析包括18项研究，而系统评价包括20项研究，总共3097名参与者(1581AR，458非AR，和1058健康/对照)。AR患者的nNO水平明显高于对照组，尽管这在治疗前或治疗后没有明显变化。AR患者的nNO水平明显高于非AR患者，但非AR患者和健康对照组之间没有显着差异。其中19项研究质量较高，其余一项研究质量中等。nNO测量在AR和非AR患者的管理中具有很好的作用，但需要更多的研究来记录临床获益.
