PDF(Pubmed)
Abstract：
OBJECTIVE: To evaluate the immediate alterations in the thickness of the macular ganglion cell-inner plexiform layer (mGCIPL), peripapillary retinal nerve fiber layer (RNFL), inner retinal layer (IRL), and outer retinal layer (ORL) using spectral domain optical coherence tomography (SD-OCT) subsequent to strabismus surgery in pediatric patients diagnosed with horizontal esotropia.
METHODS: Twenty-eight eyes from twenty-one child patients who had undergone uncomplicated horizontal rectus muscle surgery due to strabismus were included. Measurements of RNFL, mGCL-IPL, IRL, and ORL using structural OCT were conducted both before the surgery and one month after the surgical procedure. Importantly, a control group comprising 14 healthy eyes, matched for age and significant refractive error (<3.00 diopters), was included in the current analysis.
RESULTS: Our analysis indicated no significant disparity before and after surgery in terms of best-corrected visual acuity (BCVA), RNFL, IRL, and ORL. Conversely, concerning the macular ganglion cell layer-inner plexiform layer analysis, a substantial increase in mGCL-IPL was observed following the surgical intervention. The mean mGCL-IPL measured 60.8 ± 9.2 μm at baseline and 66.1 ± 13.2 μm one month after the surgery (p = 0.026). Notably, comparison between the strabismus group at baseline and the healthy group revealed a significant reduction in mGCL-IPL in the strabismus group (60.8 ± 9.2) compared to the healthy control group (68.3 ± 7.2; p = 0.014).
CONCLUSIONS: Following strabismus surgery, our observations pointed towards a thickening of the mGCL-IPL layer, which is likely attributable to transient local inflammation. Additionally, we identified a significant differentiation in the mGCL-IPL complex between the pediatric patient group with strabismus and the control group.
METHODS: Twenty-eight eyes from twenty-one child patients who had undergone uncomplicated horizontal rectus muscle surgery due to strabismus were included. Measurements of RNFL, mGCL-IPL, IRL, and ORL using structural OCT were conducted both before the surgery and one month after the surgical procedure. Importantly, a control group comprising 14 healthy eyes, matched for age and significant refractive error (<3.00 diopters), was included in the current analysis.
RESULTS: Our analysis indicated no significant disparity before and after surgery in terms of best-corrected visual acuity (BCVA), RNFL, IRL, and ORL. Conversely, concerning the macular ganglion cell layer-inner plexiform layer analysis, a substantial increase in mGCL-IPL was observed following the surgical intervention. The mean mGCL-IPL measured 60.8 ± 9.2 μm at baseline and 66.1 ± 13.2 μm one month after the surgery (p = 0.026). Notably, comparison between the strabismus group at baseline and the healthy group revealed a significant reduction in mGCL-IPL in the strabismus group (60.8 ± 9.2) compared to the healthy control group (68.3 ± 7.2; p = 0.014).
CONCLUSIONS: Following strabismus surgery, our observations pointed towards a thickening of the mGCL-IPL layer, which is likely attributable to transient local inflammation. Additionally, we identified a significant differentiation in the mGCL-IPL complex between the pediatric patient group with strabismus and the control group.
摘要：
目的：评估黄斑神经节细胞内丛状层（mGCIPL）厚度的即时改变，乳头周围视网膜神经纤维层（RNFL），视网膜内层(IRL),在诊断为水平内斜视的儿科患者中，使用谱域光学相干断层扫描（SD-OCT）和视网膜外层（ORL）。
方法：纳入21例儿童患者的28只眼，这些患者因斜视而接受了简单的水平直肌手术。RNFL的测量，mGCL-IPL,IRL,在手术前和手术后1个月使用结构OCT进行ORL。重要的是,一个由14只健康眼睛组成的对照组，年龄和显著屈光不正（<3.00屈光度）相匹配，包括在当前分析中。
结果：我们的分析表明，在最佳矫正视力（BCVA）方面，手术前后没有显着差异，RNFL,IRL,ORL。相反，关于黄斑神经节细胞层-内网状层分析，手术干预后观察到mGCL-IPL显著增加.平均mGCL-IPL在基线时测量为60.8±9.2μm，在手术后一个月测量为66.1±13.2μm（p=0.026）。值得注意的是,基线斜视组与健康组之间的比较显示,与健康对照组(68.3±7.2;p=0.014)相比,斜视组mGCL-IPL显著降低(60.8±9.2).
结论：斜视手术后，我们的观察指出mGCL-IPL层增厚，这可能归因于短暂的局部炎症。此外,我们发现,儿童斜视患者组与对照组之间mGCL-IPL复合体存在显著差异.
方法：纳入21例儿童患者的28只眼，这些患者因斜视而接受了简单的水平直肌手术。RNFL的测量，mGCL-IPL,IRL,在手术前和手术后1个月使用结构OCT进行ORL。重要的是,一个由14只健康眼睛组成的对照组，年龄和显著屈光不正（<3.00屈光度）相匹配，包括在当前分析中。
结果：我们的分析表明，在最佳矫正视力（BCVA）方面，手术前后没有显着差异，RNFL,IRL,ORL。相反，关于黄斑神经节细胞层-内网状层分析，手术干预后观察到mGCL-IPL显著增加.平均mGCL-IPL在基线时测量为60.8±9.2μm，在手术后一个月测量为66.1±13.2μm（p=0.026）。值得注意的是,基线斜视组与健康组之间的比较显示,与健康对照组(68.3±7.2;p=0.014)相比,斜视组mGCL-IPL显著降低(60.8±9.2).
结论：斜视手术后，我们的观察指出mGCL-IPL层增厚，这可能归因于短暂的局部炎症。此外,我们发现,儿童斜视患者组与对照组之间mGCL-IPL复合体存在显著差异.
