Abstract：
Silver nanoclusters (AgNCs) have emerged as versatile nanomaterials with immense potential in theranostic applications, combining therapeutic and diagnostic functions in a single platform. This review provides a comprehensive overview of recent advancements in the synthesis, characterization, and utilization of AgNCs for theranostics. The synthesis of AgNCs has witnessed significant progress, with numerous strategies such as chemical reduction, green synthesis, and templated approaches being employed to control size, shape, and stability. Their unique optical properties, including strong fluorescence and surface-enhanced Raman scattering (SERS) signals, make AgNCs ideal candidates for bioimaging and diagnostic purposes. Additionally, the surface chemistry of AgNCs allows for facile functionalization with targeting ligands and therapeutic agents, enhancing their specificity and efficacy. In the realm of diagnostics, AgNCs have been employed for various imaging modalities, including fluorescence imaging, photoacoustic imaging, and SERS-based sensing. Their excellent photostability and biocompatibility make them suitable for in vitro and in vivo imaging applications, enabling the real-time monitoring of disease progression and treatment response.
摘要：
银纳米团簇（AgNCs）已成为多功能纳米材料，在热学应用中具有巨大潜力，在单一平台中结合治疗和诊断功能。这篇综述全面概述了合成的最新进展，表征，以及AgNCs在治疗中的应用。AgNCs的合成取得了重大进展，有许多策略，如化学还原，绿色合成，以及用于控制大小的模板方法，形状,和稳定性。它们独特的光学性质，包括强荧光和表面增强拉曼散射（SERS）信号，使AgNCs成为生物成像和诊断目的的理想候选者。此外,AgNCs的表面化学允许与靶向配体和治疗剂的容易的官能化，增强其特异性和有效性。在诊断领域，AgNCs已用于各种成像模式，包括荧光成像,光声成像,和基于SERS的传感。其优异的光稳定性和生物相容性使其适用于体外和体内成像应用，能够实时监测疾病进展和治疗反应。
