PDF(Pubmed)
Abstract：
UNASSIGNED: Staphylococcus lugdunensis (S lugdunensis) is a coagulase-negative staphylococcus species that has been increasingly recognized to cause serious infections with virulence resembling Staphylococcus aureus (S aureus). No studies have evaluated the characteristics and outcomes of patients with S lugdunensis peritoneal dialysis-related peritonitis compared with those with S aureus peritonitis. We aim to evaluate the clinical course of peritonitis as caused by these organisms.
UNASSIGNED: A retrospective matched comparative analysis involving a single tertiary center from July 2000 to July 2020.
UNASSIGNED: Forty-eight episodes of S aureus peritonitis were matched to 19 cases of S lugdunensis peritonitis.
UNASSIGNED: The cases were individually matched for year of peritonitis, sex, age (±10 years), and Charlson Comorbidity Index (±3). A comparative analysis was performed between the 2 organisms. The outcome includes responses at day 5 of peritonitis and the rate of complete response.
UNASSIGNED: There is a higher predilection of diabetes in those with S aureus peritonitis than in those with S lugdunensis (64.6% vs 31.6%; P = 0.03). Patients with S aureus peritonitis also have a much higher total cell count at presentation (4,463.9 ± 5,479.5 vs 1,807.9 ± 3,322.7; P = 0.05); a higher prevalence of poor response at day 5 (50.0% vs 15.8%; P = 0.03); a lower rate of complete response (64.6% vs 94.7%; P = 0.01) and are more prone to relapse with the same organism (29.2% vs 0%, respectively; P = 0.01) as compared to those with S lugdunensis.
UNASSIGNED: The result of this small retrospective study involving a single center may not be generalizable to other centers. There is also no data for comparative analysis on other coagulase-negative staphylococci such as Staphylococcus epidermidis, which belongs to the same family as S lugdunensis.
UNASSIGNED: Although S aureus peritonitis is more virulent with significant morbidity, S lugdunensis can cause similarly serious peritonitis. This largest case series of S lugdunensis peritonitis enabled better characterization of clinical features and outcomes of patients with S lugdunensis peritonitis.
Staphylococcus lugdunensis is a coagulase-negative staphylococcus species that has been increasingly recognized to cause serious infections with virulence resembling Staphylococcus aureus. No studies have evaluated the characteristics and outcomes of patients with S lugdunensis peritoneal dialysis-related peritonitis compared those with S aureus peritonitis. This largest retrospective matched comparative analysis of S lugdunensis peritonitis enabled better characterization of clinical features and outcomes of patients with S lugdunensis. Our result suggested that although S. aureus peritonitis is more virulent with significant morbidity, S lugdunensis can cause similarly serious peritonitis. Regardless, S lugdunensis remains susceptible to most antibiotics and penicillin group, penicillin G in particular, can be considered as the first line antibiotic.
UNASSIGNED: A retrospective matched comparative analysis involving a single tertiary center from July 2000 to July 2020.
UNASSIGNED: Forty-eight episodes of S aureus peritonitis were matched to 19 cases of S lugdunensis peritonitis.
UNASSIGNED: The cases were individually matched for year of peritonitis, sex, age (±10 years), and Charlson Comorbidity Index (±3). A comparative analysis was performed between the 2 organisms. The outcome includes responses at day 5 of peritonitis and the rate of complete response.
UNASSIGNED: There is a higher predilection of diabetes in those with S aureus peritonitis than in those with S lugdunensis (64.6% vs 31.6%; P = 0.03). Patients with S aureus peritonitis also have a much higher total cell count at presentation (4,463.9 ± 5,479.5 vs 1,807.9 ± 3,322.7; P = 0.05); a higher prevalence of poor response at day 5 (50.0% vs 15.8%; P = 0.03); a lower rate of complete response (64.6% vs 94.7%; P = 0.01) and are more prone to relapse with the same organism (29.2% vs 0%, respectively; P = 0.01) as compared to those with S lugdunensis.
UNASSIGNED: The result of this small retrospective study involving a single center may not be generalizable to other centers. There is also no data for comparative analysis on other coagulase-negative staphylococci such as Staphylococcus epidermidis, which belongs to the same family as S lugdunensis.
UNASSIGNED: Although S aureus peritonitis is more virulent with significant morbidity, S lugdunensis can cause similarly serious peritonitis. This largest case series of S lugdunensis peritonitis enabled better characterization of clinical features and outcomes of patients with S lugdunensis peritonitis.
Staphylococcus lugdunensis is a coagulase-negative staphylococcus species that has been increasingly recognized to cause serious infections with virulence resembling Staphylococcus aureus. No studies have evaluated the characteristics and outcomes of patients with S lugdunensis peritoneal dialysis-related peritonitis compared those with S aureus peritonitis. This largest retrospective matched comparative analysis of S lugdunensis peritonitis enabled better characterization of clinical features and outcomes of patients with S lugdunensis. Our result suggested that although S. aureus peritonitis is more virulent with significant morbidity, S lugdunensis can cause similarly serious peritonitis. Regardless, S lugdunensis remains susceptible to most antibiotics and penicillin group, penicillin G in particular, can be considered as the first line antibiotic.
摘要：
■lugdunensis葡萄球菌（Slugdunensis）是一种凝固酶阴性的葡萄球菌，已被越来越多地认识到会引起类似金黄色葡萄球菌（Saureus）的毒力的严重感染。没有研究评估了与金黄色葡萄球菌腹膜炎相比，Slugdunensis腹膜透析相关性腹膜炎患者的特征和结局。我们旨在评估由这些生物引起的腹膜炎的临床过程。
■2000年7月至2020年7月涉及单个三级中心的回顾性匹配比较分析。
■48例金黄色葡萄球菌腹膜炎与19例S型腹膜炎相匹配。
■这些病例分别与腹膜炎的年份相匹配，性别,年龄（±10岁），和Charlson合并症指数（±3）。在2种生物体之间进行比较分析。结果包括腹膜炎第5天的反应和完全反应率。
■金黄色葡萄球菌腹膜炎患者的糖尿病好发率高于鲁敦氏杆菌（64.6％vs31.6％；P=0.03）。金黄色葡萄球菌腹膜炎患者在出现时的总细胞计数也高得多（4,463.9±5,479.5vs1,807.9±3,322.7；P=0.05）；第5天反应不良的患病率更高（50.0％vs15.8％；P=0.03）；完全缓解率更低（64.6％vs94.7％；P=0.01），并且在相同生物体下更容易复发（29.2％vs0％，分别；P=0.01），与Lugdunensis相比。
■这项涉及单个中心的小型回顾性研究的结果可能无法推广到其他中心。也没有其他凝固酶阴性葡萄球菌如表皮葡萄球菌的比较分析数据，与Lugdunensis属于同一家族。
■尽管金黄色葡萄球菌腹膜炎的毒性更强，发病率显著，Lugdunensis可引起同样严重的腹膜炎。这一系列最大的Lugdunensis腹膜炎病例可以更好地描述SLugdunensis腹膜炎患者的临床特征和预后。
鲁氏葡萄球菌是一种凝固酶阴性的葡萄球菌，已被越来越多地认识到会引起类似金黄色葡萄球菌的毒力的严重感染。没有研究评估了S腹膜透析相关性腹膜炎患者与金黄色腹膜炎相比的特征和结局。对S型腹膜炎进行的最大的回顾性匹配比较分析可以更好地描述S型腹膜炎患者的临床特征和预后。我们的结果表明，尽管金黄色葡萄球菌腹膜炎的毒性更强，发病率显著，Lugdunensis可引起同样严重的腹膜炎。无论如何,Lugdunensis仍然对大多数抗生素和青霉素组敏感，特别是青霉素G，可作为一线抗生素。
■2000年7月至2020年7月涉及单个三级中心的回顾性匹配比较分析。
■48例金黄色葡萄球菌腹膜炎与19例S型腹膜炎相匹配。
■这些病例分别与腹膜炎的年份相匹配，性别,年龄（±10岁），和Charlson合并症指数（±3）。在2种生物体之间进行比较分析。结果包括腹膜炎第5天的反应和完全反应率。
■金黄色葡萄球菌腹膜炎患者的糖尿病好发率高于鲁敦氏杆菌（64.6％vs31.6％；P=0.03）。金黄色葡萄球菌腹膜炎患者在出现时的总细胞计数也高得多（4,463.9±5,479.5vs1,807.9±3,322.7；P=0.05）；第5天反应不良的患病率更高（50.0％vs15.8％；P=0.03）；完全缓解率更低（64.6％vs94.7％；P=0.01），并且在相同生物体下更容易复发（29.2％vs0％，分别；P=0.01），与Lugdunensis相比。
■这项涉及单个中心的小型回顾性研究的结果可能无法推广到其他中心。也没有其他凝固酶阴性葡萄球菌如表皮葡萄球菌的比较分析数据，与Lugdunensis属于同一家族。
■尽管金黄色葡萄球菌腹膜炎的毒性更强，发病率显著，Lugdunensis可引起同样严重的腹膜炎。这一系列最大的Lugdunensis腹膜炎病例可以更好地描述SLugdunensis腹膜炎患者的临床特征和预后。
鲁氏葡萄球菌是一种凝固酶阴性的葡萄球菌，已被越来越多地认识到会引起类似金黄色葡萄球菌的毒力的严重感染。没有研究评估了S腹膜透析相关性腹膜炎患者与金黄色腹膜炎相比的特征和结局。对S型腹膜炎进行的最大的回顾性匹配比较分析可以更好地描述S型腹膜炎患者的临床特征和预后。我们的结果表明，尽管金黄色葡萄球菌腹膜炎的毒性更强，发病率显著，Lugdunensis可引起同样严重的腹膜炎。无论如何,Lugdunensis仍然对大多数抗生素和青霉素组敏感，特别是青霉素G，可作为一线抗生素。
