PDF(Pubmed)
Abstract：
UNASSIGNED: Respiratory infections are a major global health concern, with Klebsiella pneumoniae standing out due to its evolving antibiotic resistance. This study compares the resistance profiles of hypervirulent Klebsiella pneumoniae (hvKP) and classical Klebsiella pneumoniae (cKP), aiming to shed light on their clinical implications.
UNASSIGNED: We analyzed 86 cases, comprising 42 hvKP and 44 cKP strains, using comprehensive antimicrobial susceptibility testing and clinical data evaluation to assess antibiotic tolerance and resistance mechanisms.
UNASSIGNED: Our findings reveal distinct resistance patterns between hvKP and cKP, highlighting the role of chromosomal mutations and plasmid-mediated gene transfer in conferring antibiotic resistance. Notably, hvKP strains exhibited unique resistance trends, including the production of extended-spectrum β-lactamases (ESBLs) and carbapenemases, differing from those of cKP.
UNASSIGNED: This research underscores the importance of continuous surveillance and the development of targeted therapies against antibiotic-resistant Klebsiella pneumoniae. It emphasizes the critical need for judicious antibiotic use and novel therapeutic approaches to combat respiratory infections caused by these increasingly resistant pathogens.
UNASSIGNED: We analyzed 86 cases, comprising 42 hvKP and 44 cKP strains, using comprehensive antimicrobial susceptibility testing and clinical data evaluation to assess antibiotic tolerance and resistance mechanisms.
UNASSIGNED: Our findings reveal distinct resistance patterns between hvKP and cKP, highlighting the role of chromosomal mutations and plasmid-mediated gene transfer in conferring antibiotic resistance. Notably, hvKP strains exhibited unique resistance trends, including the production of extended-spectrum β-lactamases (ESBLs) and carbapenemases, differing from those of cKP.
UNASSIGNED: This research underscores the importance of continuous surveillance and the development of targeted therapies against antibiotic-resistant Klebsiella pneumoniae. It emphasizes the critical need for judicious antibiotic use and novel therapeutic approaches to combat respiratory infections caused by these increasingly resistant pathogens.
摘要：
呼吸道感染是全球主要的健康问题，肺炎克雷伯菌由于其不断发展的抗生素耐药性而脱颖而出。这项研究比较了高毒力肺炎克雷伯菌（hvKP）和经典肺炎克雷伯菌（cKP）的耐药性，旨在阐明其临床意义。
■我们分析了86例，包括42个hvKP和44个cKP菌株，使用全面的抗菌药物敏感性测试和临床数据评估来评估抗生素耐受和耐药机制。
■我们的发现揭示了hvKP和cKP之间不同的阻力模式，强调染色体突变和质粒介导的基因转移在赋予抗生素耐药性中的作用。值得注意的是,hvKP菌株表现出独特的抗性趋势，包括广谱β-内酰胺酶（ESBLs）和碳青霉烯酶的生产，与cKP不同。
■这项研究强调了持续监测和开发针对抗生素耐药肺炎克雷伯菌的靶向治疗的重要性。它强调了对明智的抗生素使用和新的治疗方法的迫切需要，以对抗由这些日益耐药的病原体引起的呼吸道感染。
■我们分析了86例，包括42个hvKP和44个cKP菌株，使用全面的抗菌药物敏感性测试和临床数据评估来评估抗生素耐受和耐药机制。
■我们的发现揭示了hvKP和cKP之间不同的阻力模式，强调染色体突变和质粒介导的基因转移在赋予抗生素耐药性中的作用。值得注意的是,hvKP菌株表现出独特的抗性趋势，包括广谱β-内酰胺酶（ESBLs）和碳青霉烯酶的生产，与cKP不同。
■这项研究强调了持续监测和开发针对抗生素耐药肺炎克雷伯菌的靶向治疗的重要性。它强调了对明智的抗生素使用和新的治疗方法的迫切需要，以对抗由这些日益耐药的病原体引起的呼吸道感染。
