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Abstract：
High temperature requirement A1 (HTRA1) is a member of the serine protease family, comprising four structural domains: IGFBP domain, Kazal domain, protease domain and PDZ domain. HTRA1 encodes a serine protease, a secreted protein that is widely expressed in the vasculature. HTRA1 regulates a wide range of physiological processes through its proteolytic activity, and is also involved in a variety of vascular abnormalities-related diseases. This article reviews the role of HTRA1 in the development of vascular abnormalities-related hereditary cerebral small vessel disease (CSVD), age-related macular degeneration (AMD), tumors and other diseases. Through relevant research advances to understand the role of HTRA1 in regulating signaling pathways or refolding, translocation, degradation of extracellular matrix (ECM) proteins, thus directly or indirectly regulating angiogenesis, vascular remodeling, and playing an important role in vascular homeostasis, further understanding the mechanism of HTRA1\'s role in vascular abnormality-related diseases is important for HTRA1 to be used as a therapeutic target in related diseases.
摘要：
高温要求A1（HTRA1）是丝氨酸蛋白酶家族的成员，包含四个结构域：IGFBP结构域，Kazal域,蛋白酶结构域和PDZ结构域。HTRA1编码一种丝氨酸蛋白酶，在脉管系统中广泛表达的分泌蛋白。HTRA1通过其蛋白水解活性调节广泛的生理过程，并参与多种血管异常相关疾病。本文综述了HTRA1在血管异常相关遗传性脑小血管病(CSVD)发生发展中的作用,年龄相关性黄斑变性（AMD），肿瘤和其他疾病。通过相关研究进展了解HTRA1在调节信号通路或重折叠中的作用,易位,细胞外基质（ECM）蛋白的降解，因此直接或间接调节血管生成，血管重塑,在血管稳态中发挥重要作用，进一步了解HTRA1在血管异常相关疾病中的作用机制对于HTRA1作为相关疾病的治疗靶点具有重要意义。
