Abstract：
UNASSIGNED: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI), which are prevalent conditions among post-9/11 veterans, increase risks of rapid eye movement (REM) sleep behavior disorder (RBD) and degenerative synucleinopathy. Rates and predictors of RBD symptoms were investigated by screening post-9/11 veterans for RBD with a validated questionnaire.
UNASSIGNED: In this cross-sectional analysis, consecutive patients in the Houston Translational Research Center for TBI and Stress Disorders (TRACTS) were screened with the English translation of the RBD Questionnaire-Hong Kong (RBDQ-HK). In addition to data from the standard TRACTS battery, systematic chart review was used to identify known sleep disorders mimicking or manifesting RBD.
UNASSIGNED: Of the 119 patients with available RBDQ-HK scores, 71 (60%) and 65 (55%) screened positive for RBD, when a total score ≥21 and a factor 2 score ≥8 were used as cutoff scores, respectively. Univariable analyses with both cutoffs showed consistent associations between a positive RBDQ-HK screen and global sleep quality, number of TBI exposures, and PTSD severity. Multivariable logistic regression with total score ≥21 as a cutoff indicated that PTSD severity (odds ratio=1.06, 95% CI=1.02-1.10) and number of TBIs (odds ratio=1.63, 95% CI=1.16-2.41) were independent predictors of a positive screen, whereas global sleep quality was no longer significant. Multivariable logistic regression with factor 2 score ≥8 as a cutoff showed similar results.
UNASSIGNED: Interdisciplinary parasomnia assessment, further validation of RBD screens, and standardized reporting of REM sleep without atonia could provide necessary information on the pathophysiological relationships linking PTSD, TBI, RBD symptoms, and ultimately synucleinopathy risk among post-9/11 veterans.
UNASSIGNED: In this cross-sectional analysis, consecutive patients in the Houston Translational Research Center for TBI and Stress Disorders (TRACTS) were screened with the English translation of the RBD Questionnaire-Hong Kong (RBDQ-HK). In addition to data from the standard TRACTS battery, systematic chart review was used to identify known sleep disorders mimicking or manifesting RBD.
UNASSIGNED: Of the 119 patients with available RBDQ-HK scores, 71 (60%) and 65 (55%) screened positive for RBD, when a total score ≥21 and a factor 2 score ≥8 were used as cutoff scores, respectively. Univariable analyses with both cutoffs showed consistent associations between a positive RBDQ-HK screen and global sleep quality, number of TBI exposures, and PTSD severity. Multivariable logistic regression with total score ≥21 as a cutoff indicated that PTSD severity (odds ratio=1.06, 95% CI=1.02-1.10) and number of TBIs (odds ratio=1.63, 95% CI=1.16-2.41) were independent predictors of a positive screen, whereas global sleep quality was no longer significant. Multivariable logistic regression with factor 2 score ≥8 as a cutoff showed similar results.
UNASSIGNED: Interdisciplinary parasomnia assessment, further validation of RBD screens, and standardized reporting of REM sleep without atonia could provide necessary information on the pathophysiological relationships linking PTSD, TBI, RBD symptoms, and ultimately synucleinopathy risk among post-9/11 veterans.
摘要：
■创伤后应激障碍（PTSD）和创伤性脑损伤（TBI），这是9/11后退伍军人的普遍状况，增加快速眼动（REM）睡眠行为障碍（RBD）和退行性突触核蛋白病的风险。通过使用经过验证的问卷筛查9/11后的RBD退伍军人，调查了RBD症状的发生率和预测因子。
■在此横截面分析中，休斯顿TBI和应激障碍转化研究中心(TRACTS)的连续患者通过RBD问卷-香港(RBDQ-HK)的英文翻译进行筛选.除了标准TRACTS电池的数据，系统图表回顾用于确定已知的模仿或表现为RBD的睡眠障碍.
■在119名具有可用RBDQ-HK评分的患者中，71（60%）和65（55%）RBD筛查阳性，当总分≥21分和因子2分≥8分作为截止分数时，分别。具有两个截止点的单变量分析显示，RBDQ-HK筛查阳性与全球睡眠质量之间存在一致的关联，TBI暴露的数量，和创伤后应激障碍的严重性。以总分≥21为截止值的多变量逻辑回归表明，PTSD严重程度（比值比=1.06，95％CI=1.02-1.10）和TBI数量（比值比=1.63，95％CI=1.16-2.41）是阳性筛查的独立预测因子。而全球睡眠质量不再显著。以因子2评分≥8为截止值的多变量逻辑回归显示出相似的结果。
■跨学科的失眠症评估，RBD屏幕的进一步验证，和无张力的REM睡眠的标准化报告可以提供有关PTSD的病理生理关系的必要信息，TBI,RBD症状,以及9/11后退伍军人中最终的突触核蛋白病风险。
■在此横截面分析中，休斯顿TBI和应激障碍转化研究中心(TRACTS)的连续患者通过RBD问卷-香港(RBDQ-HK)的英文翻译进行筛选.除了标准TRACTS电池的数据，系统图表回顾用于确定已知的模仿或表现为RBD的睡眠障碍.
■在119名具有可用RBDQ-HK评分的患者中，71（60%）和65（55%）RBD筛查阳性，当总分≥21分和因子2分≥8分作为截止分数时，分别。具有两个截止点的单变量分析显示，RBDQ-HK筛查阳性与全球睡眠质量之间存在一致的关联，TBI暴露的数量，和创伤后应激障碍的严重性。以总分≥21为截止值的多变量逻辑回归表明，PTSD严重程度（比值比=1.06，95％CI=1.02-1.10）和TBI数量（比值比=1.63，95％CI=1.16-2.41）是阳性筛查的独立预测因子。而全球睡眠质量不再显著。以因子2评分≥8为截止值的多变量逻辑回归显示出相似的结果。
■跨学科的失眠症评估，RBD屏幕的进一步验证，和无张力的REM睡眠的标准化报告可以提供有关PTSD的病理生理关系的必要信息，TBI,RBD症状,以及9/11后退伍军人中最终的突触核蛋白病风险。
