Abstract：
We attempted to clarify clinical value of KiSS-1 and MMP-2 levels in breast cancer (BC) tissue in evaluating prognosis of elderly BC patients after modified radical mastectomy (MCM). The data of 192 elderly female BC patients receiving MCM in our hospital from January 2018 to December 2022 were collected. According to prognosis, patients received division into poor prognosis group (n = 43) and good prognosis group (n = 149). The serum CEA level and KiSS-1 and MMP-2 levels in BC tissue received measurement in both groups. The predictive value of KiSS-1 and MMP-2 alone and jointly in adverse prognosis of elderly BC patients after MCM received assessment. Results showed that No statistical significance was exhibited between both groups in general data (P > 0.05). The serum CEA level and MMP-2 expression in BC tissue in poor prognosis group exhibited elevation relative to those in good prognosis group, and KiSS-1 expression in BC tissue in poor prognosis group exhibited depletion relative to that in good prognosis group, indicating statistical significance (P < 0.05). The high-level KiSS-1 might be a protective element for adverse prognosis of elderly BC patients after MCM, and high-level CEA and MMP-2 might be an independent risk element for adverse prognosis of elderly BC patients after MCM (P < 0.05). KiSS-1 and MMP-2 alone and jointly predicted AUC of adverse prognosis in elderly BC patients after MCM were 0.93, 0.802 and 0.958, with certain predictive values; when cutoff values of KiSS-1 and MMP-2 were 6.15 and 2.26, the predictive value was the best. In conclusion, KiSS-1 and MMP-2 levels in BC tissue possess relation to adverse prognosis of MCM. KiSS-1 and MMP-2 levels in elderly BC patients before surgery may be detected in the future to assist in prognosis evaluation of elderly BC patients after MCM.
摘要：
我们试图阐明乳腺癌（BC）组织中KiSS-1和MMP-2水平在评估老年BC患者改良根治术（MCM）预后中的临床价值。收集2018年1月至2022年12月在我院接受MCM治疗的老年女性BC患者192例资料。根据预后,将患者分为预后不良组(n=43)和预后良好组(n=149)。检测两组患者血清CEA水平、BC组织KiSS-1和MMP-2水平。KiSS-1和MMP-2单独及联合检测对老年BC患者MCM后不良预后的预测价值。结果两组一般资料比较差异无统计学意义(P>0.05)。预后不良组的血清CEA水平和BC组织MMP-2表达相对于预后良好组升高，预后不良组BC组织中KiSS-1的表达相对于预后良好组表现出减少，有统计学意义(P<0.05)。高水平的KiSS-1可能是老年BC患者MCM术后不良预后的保护因素,高CEA和MMP-2水平可能是老年BC患者MCM术后不良预后的独立危险因素(P<0.05)。KiSS-1和MMP-2单独及联合预测老年BC患者MCM术后不良预后的AUC分别为0.93、0.802和0.958，具有一定的预测价值；当KiSS-1和MMP-2的临界值分别为6.15和2.26时，预测价值最好。总之,BC组织中KiSS-1和MMP-2水平与MCM的不良预后有关。术前检测老年BC患者的KiSS-1和MMP-2水平可能有助于MCM后老年BC患者预后评估。
