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Abstract：
OBJECTIVE: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT.
METHODS: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with <10% missing data in univariate analysis were considered for the multivariate logistic regression model.
RESULTS: Of the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female-predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p < 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5-60) versus 40 (33-47) years in the coma (p = 0.04) and 44.5 (34-58) versus 37 (29-48) years in the non-coma sample (p < 0.001), respectively. Furthermore, an age- and superior sagittal sinus-adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0-3.4, p = 0.04) to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52-0.68, p = 0.01).
CONCLUSIONS: Although CVT is a female-predominant disease, men were older and nearly twice as likely to suffer from coma than women.
METHODS: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with <10% missing data in univariate analysis were considered for the multivariate logistic regression model.
RESULTS: Of the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female-predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p < 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5-60) versus 40 (33-47) years in the coma (p = 0.04) and 44.5 (34-58) versus 37 (29-48) years in the non-coma sample (p < 0.001), respectively. Furthermore, an age- and superior sagittal sinus-adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0-3.4, p = 0.04) to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52-0.68, p = 0.01).
CONCLUSIONS: Although CVT is a female-predominant disease, men were older and nearly twice as likely to suffer from coma than women.
摘要：
目的：昏迷是脑静脉血栓形成（CVT）不良临床结局的独立预测因子。我们的目的是描述年龄的关联，性别,和成人CVT昏迷患者的放射学特征。
方法：我们使用了来自国际，多中心前瞻性观察BEAST（建立动静脉血栓形成病因的生物栓剂）研究。在多变量逻辑回归模型中，仅考虑与昏迷呈正相关的变量，单变量分析中缺失数据<10％。
结果：在596名患有CVT的成年患者中（75.7％为女性），53例（8.9％）患者昏迷。尽管是女性为主的疾病，男性昏迷的患病率高于女性(13.1%vs.7.5%,p=0.04)。横窦血栓形成最不可能与昏迷相关(23.9%vs.73.3%,p<0.001)。在昏迷样本中，男性上矢状窦血栓形成的患病率高于女性(73.6%vs.37.5%,p=0.01)。男性明显比女性年长，昏迷患者的中位年龄（四分位距）为51岁（38.5-60）对40岁（33-47）（p=0.04），非昏迷患者为44.5岁（34-58）对37岁（29-48）（p<0.001），分别。此外，年龄和上矢状窦调整的多变量逻辑回归模型发现，男性（比值比=1.8，95％置信区间[CI]=1.0-3.4，p=0.04）是CVT昏迷的独立预测因子，受试者工作特征曲线下面积为0.61（95％CI=0.52-0.68，p=0.01）。
结论：虽然CVT是一种以女性为主的疾病，男性年龄较大，昏迷的可能性几乎是女性的两倍。
方法：我们使用了来自国际，多中心前瞻性观察BEAST（建立动静脉血栓形成病因的生物栓剂）研究。在多变量逻辑回归模型中，仅考虑与昏迷呈正相关的变量，单变量分析中缺失数据<10％。
结果：在596名患有CVT的成年患者中（75.7％为女性），53例（8.9％）患者昏迷。尽管是女性为主的疾病，男性昏迷的患病率高于女性(13.1%vs.7.5%,p=0.04)。横窦血栓形成最不可能与昏迷相关(23.9%vs.73.3%,p<0.001)。在昏迷样本中，男性上矢状窦血栓形成的患病率高于女性(73.6%vs.37.5%,p=0.01)。男性明显比女性年长，昏迷患者的中位年龄（四分位距）为51岁（38.5-60）对40岁（33-47）（p=0.04），非昏迷患者为44.5岁（34-58）对37岁（29-48）（p<0.001），分别。此外，年龄和上矢状窦调整的多变量逻辑回归模型发现，男性（比值比=1.8，95％置信区间[CI]=1.0-3.4，p=0.04）是CVT昏迷的独立预测因子，受试者工作特征曲线下面积为0.61（95％CI=0.52-0.68，p=0.01）。
结论：虽然CVT是一种以女性为主的疾病，男性年龄较大，昏迷的可能性几乎是女性的两倍。
