METHODS: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with <10% missing data in univariate analysis were considered for the multivariate logistic regression model.
RESULTS: Of the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female-predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p < 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5-60) versus 40 (33-47) years in the coma (p = 0.04) and 44.5 (34-58) versus 37 (29-48) years in the non-coma sample (p < 0.001), respectively. Furthermore, an age- and superior sagittal sinus-adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0-3.4, p = 0.04) to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52-0.68, p = 0.01).
CONCLUSIONS: Although CVT is a female-predominant disease, men were older and nearly twice as likely to suffer from coma than women.
方法:我们使用了来自国际,多中心前瞻性观察BEAST(建立动静脉血栓形成病因的生物栓剂)研究。在多变量逻辑回归模型中,仅考虑与昏迷呈正相关的变量,单变量分析中缺失数据<10%。
结果:在596名患有CVT的成年患者中(75.7%为女性),53例(8.9%)患者昏迷。尽管是女性为主的疾病,男性昏迷的患病率高于女性(13.1%vs.7.5%,p=0.04)。横窦血栓形成最不可能与昏迷相关(23.9%vs.73.3%,p<0.001)。在昏迷样本中,男性上矢状窦血栓形成的患病率高于女性(73.6%vs.37.5%,p=0.01)。男性明显比女性年长,昏迷患者的中位年龄(四分位距)为51岁(38.5-60)对40岁(33-47)(p=0.04),非昏迷患者为44.5岁(34-58)对37岁(29-48)(p<0.001),分别。此外,年龄和上矢状窦调整的多变量逻辑回归模型发现,男性(比值比=1.8,95%置信区间[CI]=1.0-3.4,p=0.04)是CVT昏迷的独立预测因子,受试者工作特征曲线下面积为0.61(95%CI=0.52-0.68,p=0.01)。
结论:虽然CVT是一种以女性为主的疾病,男性年龄较大,昏迷的可能性几乎是女性的两倍。