A Rare Case of Dual Metachronous Primary Malignancies, Chronic Myeloid Leukemia, and Tongue Carcinoma in a Patient With Long-Standing Systemic Lupus Erythematosus: A Case Report and Review of Literature.

一例罕见的双重异时原发恶性肿瘤,慢性髓系白血病,长期系统性红斑狼疮患者舌癌 ： 病例报告和文献复习。

• 发表时间: 2024 Mar
• 来源期刊: Cureus
• DOI: 10.7759/cureus.56648
• PMID: 38646281
• 文章类型: Case Reports
• 作者列表: BalajiSubramanian S,Al-Hajri T,Satyapal N,Al-Bulushi M,Al Sheibani SM,Al Kalbani FKM,Al-Saadi M,Al Musalhi MN,Al Wahshi HA

关键词: autoimmune; chronic myeloid leukemia; dasatinib; head and neck cancer; hematological malignancies; radiotherapy; systemic lupus erythematosus; tongue carcinoma; vmat

Abstract

Patients with long-standing autoimmune diseases like systemic lupus erythematosus (SLE) are at a higher risk of developing hematological malignancies. However, chronic myeloid leukemia (CML) has rarely been reported in patients with SLE. Advancements in medical diagnostics and treatment have led to the life expectancy of SLE and CML patients moving closer to that of the general population, and it is not uncommon to encounter more than one malignancy in a cancer survivor. Although squamous cell carcinoma (SCC) of the skin has been reported in CML patients, mucosal SCC of the head and neck has rarely only been reported in CML survivors. The objective of this case report is to share our experience in treating a patient with dual metachronous primary malignancies, CML, and tongue carcinoma, along with long-standing SLE, managed by a multidisciplinary team.

摘要

患有系统性红斑狼疮（SLE）等长期自身免疫性疾病的患者患血液恶性肿瘤的风险更高。然而,慢性粒细胞白血病（CML）在SLE患者中的报道很少。医学诊断和治疗的进步导致SLE和CML患者的预期寿命接近普通人群，在癌症幸存者中遇到一个以上的恶性肿瘤并不少见。尽管已经报道了CML患者的皮肤鳞状细胞癌（SCC），很少仅在CML幸存者中报告头颈部粘膜SCC.本病例报告的目的是分享我们治疗患有双重异时性原发性恶性肿瘤的患者的经验。CML,和舌癌，以及长期存在的SLE,由一个多学科团队管理。