PDF(Pubmed)
Abstract：
We reported a 51-year-old male electric welder with stage I pneumoconiosis, who had no significant cough, sputum, fever, chest pain, or other discomfort. However, regular physical examination at our hospital revealed bilateral pulmonary nodules with cavity formation. Blood routine, liver or kidney function, and infection-related biomarkers, including interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and procalcitonin (PCT), were normal. Sputum and alveolar lavage fluid (BALF) acid-fast bacilli (AFB) smears, BALF Mycobacterium tuberculosis (TB) PCR, and T-SPOT.TB were negative. The nucleic acid sequence of Mycobacterium europaeum was detected by BALF metagenomic next-generation sequencing (mNGS), which was confirmed by the subsequent positive culture for NTM. Considering stable conditions, no significant discomfort, and no significant changes in the lung lesion, the patient was diagnosed with inactive nontuberculous mycobacterial pulmonary disease (NTM-PD).
摘要：
我们报告了一名51岁的男性电焊工患有I期尘肺，没有明显咳嗽，痰,发烧,胸痛,或其他不适。然而,在我院定期体检发现双侧肺结节有空洞形成。血常规,肝脏或肾脏功能，和感染相关的生物标志物，包括白细胞介素-6（IL-6），高敏C反应蛋白(hs-CRP),和降钙素原（PCT），是正常的。痰和肺泡灌洗液（BALF）抗酸杆菌（AFB）涂片，BALF结核分枝杆菌（TB）PCR，还有T-SPOT.TB为阴性。通过BALF宏基因组下一代测序（mNGS）检测欧洲分枝杆菌的核酸序列，随后的NTM阳性培养证实了这一点。考虑到稳定的条件，没有明显的不适，肺部病变没有明显变化，患者被诊断为非活动性非结核分枝杆菌肺病(NTM-PD).
