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Abstract：
Craniomaxillofacial development involves a series of highly ordered temporal-spatial cellular differentiation processes in which a variety of cell signaling factors, such as fibroblast growth factors, play important regulatory roles. As a classic fibroblast growth factor, fibroblast growth factor 7 (FGF7) serves a wide range of regulatory functions. Previous studies have demonstrated that FGF7 regulates the proliferation and migration of epithelial cells, protects them, and promotes their repair. Furthermore, recent findings indicate that epithelial cells are not the only ones subjected to the broad and powerful regulatory capacity of FGF7. It has potential effects on skeletal system development as well. In addition, FGF7 plays an important role in the development of craniomaxillofacial organs, such as the palate, the eyes, and the teeth. Nonetheless, the role of FGF7 in oral craniomaxillofacial development needs to be further elucidated. In this paper, we summarized the published research on the role of FGF7 in oral craniomaxillofacial development to demonstrate the overall understanding of FGF7 and its potential functions in oral craniomaxillofacial development.
摘要：
颅颌面发育涉及一系列高度有序的时空细胞分化过程,如成纤维细胞生长因子，发挥重要的调节作用。作为一种经典的成纤维细胞生长因子，成纤维细胞生长因子7（FGF7）具有广泛的调节功能。先前的研究表明，FGF7调节上皮细胞的增殖和迁移，保护他们,并促进他们的修复。此外，最近的发现表明，上皮细胞并不是唯一受到FGF7广泛而强大的调节能力的细胞。它对骨骼系统的发育也有潜在的影响。此外,FGF7在颅颌面器官的发育中起着重要作用，比如味觉，眼睛,还有牙齿.尽管如此，FGF7在口腔颅颌面发育中的作用有待进一步阐明.在本文中,我们总结了已发表的关于FGF7在口腔颅颌面发育中的作用的研究，以证明对FGF7及其在口腔颅颌面发育中的潜在功能的全面理解。
