PDF(Pubmed)
Abstract：
UNASSIGNED: The objective of this study was to analyze all available research on the application of autologous fat grafting (AFG) and adipose-derived stem cells (ADSC) to present evidence-based recommendations, particularly in the clinical treatment of acute burns and burn-related scars.
UNASSIGNED: We conducted a systematic search of PubMed, COCHRANE, and EMBASE, as well as a manual search of previous reviews\' reference lists up. The risk of bias (RoB) was assessed using RoB 2.0 and ROBINS-I, where appropriate.
UNASSIGNED: Six eligible studies were selected (2 randomized clinical trials [RCT], 1 retrospective cohort, and 3 experimental studies) with subjects ranging from 3 to 100. Only one study evaluated the use of AFG for acute burns. Improvements in wound healing, vascularization, scar characteristics, and tissue architecture were generally observed in some studies, supported by molecular markers, while one study reported nonsignificant results. Subjective patient satisfaction was reported to have improved. Functional outcomes improvement in the treated regions was minimal. However, study heterogeneity arose mainly from treatment protocols. Cautious results interpretation due to potential bias, especially in selection and confounding domains, and limited clinical trials are important to note. More studies are needed to evaluate.
UNASSIGNED: AFG and ADSC hold potential as valuable treatment options for burn-related scars, supported by a body of evidence, but further well-designed RCT are needed. The efficacy of acute burn settings is yet to be further evaluated since evidence is limited.
UNASSIGNED: We conducted a systematic search of PubMed, COCHRANE, and EMBASE, as well as a manual search of previous reviews\' reference lists up. The risk of bias (RoB) was assessed using RoB 2.0 and ROBINS-I, where appropriate.
UNASSIGNED: Six eligible studies were selected (2 randomized clinical trials [RCT], 1 retrospective cohort, and 3 experimental studies) with subjects ranging from 3 to 100. Only one study evaluated the use of AFG for acute burns. Improvements in wound healing, vascularization, scar characteristics, and tissue architecture were generally observed in some studies, supported by molecular markers, while one study reported nonsignificant results. Subjective patient satisfaction was reported to have improved. Functional outcomes improvement in the treated regions was minimal. However, study heterogeneity arose mainly from treatment protocols. Cautious results interpretation due to potential bias, especially in selection and confounding domains, and limited clinical trials are important to note. More studies are needed to evaluate.
UNASSIGNED: AFG and ADSC hold potential as valuable treatment options for burn-related scars, supported by a body of evidence, but further well-designed RCT are needed. The efficacy of acute burn settings is yet to be further evaluated since evidence is limited.
摘要：
■这项研究的目的是分析所有关于自体脂肪移植（AFG）和脂肪干细胞（ADSC）应用的现有研究，以提出循证建议。特别是在急性烧伤和烧伤相关疤痕的临床治疗中。
■我们对PubMed进行了系统搜索，Cochrane,和EMBASE,以及手动搜索以前的评论\'参考列表。使用RoB2.0和ROBINS-I评估偏倚风险(RoB)，在适当的地方。
■选择了六项符合条件的研究（2项随机临床试验[RCT]，1个回顾性队列，和3项实验研究），受试者范围从3到100。只有一项研究评估了AFG在急性烧伤中的应用。改善伤口愈合，血管化,疤痕特征，在一些研究中通常观察到组织结构，由分子标记支持，而一项研究报告结果不显著。据报道，患者主观满意度有所改善。治疗区域的功能结果改善最小。然而,研究异质性主要来自治疗方案。由于潜在的偏差，谨慎的结果解释，特别是在选择和混淆领域，和有限的临床试验是重要的注意。需要更多的研究来评估。
■AFG和ADSC具有作为烧伤相关疤痕的有价值的治疗选择的潜力，有大量证据支持,但需要进一步精心设计的RCT。由于证据有限，急性烧伤的疗效有待进一步评估。
■我们对PubMed进行了系统搜索，Cochrane,和EMBASE,以及手动搜索以前的评论\'参考列表。使用RoB2.0和ROBINS-I评估偏倚风险(RoB)，在适当的地方。
■选择了六项符合条件的研究（2项随机临床试验[RCT]，1个回顾性队列，和3项实验研究），受试者范围从3到100。只有一项研究评估了AFG在急性烧伤中的应用。改善伤口愈合，血管化,疤痕特征，在一些研究中通常观察到组织结构，由分子标记支持，而一项研究报告结果不显著。据报道，患者主观满意度有所改善。治疗区域的功能结果改善最小。然而,研究异质性主要来自治疗方案。由于潜在的偏差，谨慎的结果解释，特别是在选择和混淆领域，和有限的临床试验是重要的注意。需要更多的研究来评估。
■AFG和ADSC具有作为烧伤相关疤痕的有价值的治疗选择的潜力，有大量证据支持,但需要进一步精心设计的RCT。由于证据有限，急性烧伤的疗效有待进一步评估。
