PDF(Pubmed)
Abstract：
UNASSIGNED: Understanding factors that influence blood glucose levels in patients with type 2 diabetes mellitus (T2DM) is crucial for managing hyperglycemia. Currently, there is no standardized interpretation method for glucagon levels in oral glucose tolerance test (OGTT). This study aims to assess the relationship between the lowest glucagon/highest C-peptide ratio (Lglc/Hcp) in OGTT and glucose control levels in T2DM.
UNASSIGNED: Clinical data from 120 patients with T2DM were examined to compare the correlations of Lglc/Hcp and other pancreatic islet function-associated indices with fasting blood glucose (G0), glucose at 120 minutes in OGTT (G120), hemoglobin A1c (HbA1c), and the area under the glucose curve in OGTT (AUCglu). Additionally, the study investigated difference in Lglc/Hcp between patient groups based on the highest blood glucose levels (Hglu) in OGTT (Hglu ≥ 16.7 mmol/L vs Hglu < 16.7 mmol/L).
UNASSIGNED: The generalized linear model suggested that Lglc/Hcp significantly correlated with G0 (B = 0.85, P < 0.001), G120(B = 1.46, P < 0.001), HbA1c (B = 0.67, P < 0.001), and AUCglu (B = 3.46, P < 0.001). This correlation surpassed C-peptide and glucagon-related parameters, even after adjusting for confounding factors. Furthermore, Lglc/Hcp was notably higher in patients with Hglu ≥ 16.7 mmol/L compared to those with Hglu < 16.7 mmol/L (Z = -3.71, p < 0.001).
UNASSIGNED: Lglc/Hcp in OGTT closely relates to blood glucose control in patients with T2DM, potentially reflecting the overall pancreatic islet function in regulating glucose levels. Moreover, inhibiting glucagon secretion may be a crucial consideration for patients requiring insulin treatment.
UNASSIGNED: Clinical data from 120 patients with T2DM were examined to compare the correlations of Lglc/Hcp and other pancreatic islet function-associated indices with fasting blood glucose (G0), glucose at 120 minutes in OGTT (G120), hemoglobin A1c (HbA1c), and the area under the glucose curve in OGTT (AUCglu). Additionally, the study investigated difference in Lglc/Hcp between patient groups based on the highest blood glucose levels (Hglu) in OGTT (Hglu ≥ 16.7 mmol/L vs Hglu < 16.7 mmol/L).
UNASSIGNED: The generalized linear model suggested that Lglc/Hcp significantly correlated with G0 (B = 0.85, P < 0.001), G120(B = 1.46, P < 0.001), HbA1c (B = 0.67, P < 0.001), and AUCglu (B = 3.46, P < 0.001). This correlation surpassed C-peptide and glucagon-related parameters, even after adjusting for confounding factors. Furthermore, Lglc/Hcp was notably higher in patients with Hglu ≥ 16.7 mmol/L compared to those with Hglu < 16.7 mmol/L (Z = -3.71, p < 0.001).
UNASSIGNED: Lglc/Hcp in OGTT closely relates to blood glucose control in patients with T2DM, potentially reflecting the overall pancreatic islet function in regulating glucose levels. Moreover, inhibiting glucagon secretion may be a crucial consideration for patients requiring insulin treatment.
摘要：
■了解影响2型糖尿病（T2DM）患者血糖水平的因素对于控制高血糖至关重要。目前,口服葡萄糖耐量试验(OGTT)中胰高血糖素水平没有标准化的解释方法.这项研究旨在评估OGTT中最低胰高血糖素/最高C肽比率（Lglc/Hcp）与T2DM中葡萄糖控制水平之间的关系。
■研究了120例T2DM患者的临床数据，以比较Lglc/Hcp和其他胰岛功能相关指标与空腹血糖（G0）的相关性。在OGTT（G120）中120分钟时的葡萄糖，血红蛋白A1c（HbA1c），和OGTT中的葡萄糖曲线下面积(AUCglu)。此外,该研究根据OGTT中的最高血糖水平(Hglu)(Hglu≥16.7mmol/LvsHglu<16.7mmol/L)调查了患者组之间Lglc/Hcp的差异.
■广义线性模型表明Lglc/Hcp与G0显著相关(B=0.85,P<0.001),G120(B=1.46,P<0.001),HbA1c(B=0.67,P<0.001),AUCglu(B=3.46,P<0.001)。这种相关性超过了C肽和胰高血糖素相关参数，即使在调整了混杂因素之后。此外，Hglu≥16.7mmol/L的患者Lglc/Hcp明显高于Hglu<16.7mmol/L的患者(Z=-3.71,p<0.001)。
■OGTT中Lglc/Hcp与T2DM患者血糖控制密切相关,潜在地反映了胰岛在调节葡萄糖水平方面的整体功能。此外，对于需要胰岛素治疗的患者,抑制胰高血糖素分泌可能是至关重要的考虑因素.
■研究了120例T2DM患者的临床数据，以比较Lglc/Hcp和其他胰岛功能相关指标与空腹血糖（G0）的相关性。在OGTT（G120）中120分钟时的葡萄糖，血红蛋白A1c（HbA1c），和OGTT中的葡萄糖曲线下面积(AUCglu)。此外,该研究根据OGTT中的最高血糖水平(Hglu)(Hglu≥16.7mmol/LvsHglu<16.7mmol/L)调查了患者组之间Lglc/Hcp的差异.
■广义线性模型表明Lglc/Hcp与G0显著相关(B=0.85,P<0.001),G120(B=1.46,P<0.001),HbA1c(B=0.67,P<0.001),AUCglu(B=3.46,P<0.001)。这种相关性超过了C肽和胰高血糖素相关参数，即使在调整了混杂因素之后。此外，Hglu≥16.7mmol/L的患者Lglc/Hcp明显高于Hglu<16.7mmol/L的患者(Z=-3.71,p<0.001)。
■OGTT中Lglc/Hcp与T2DM患者血糖控制密切相关,潜在地反映了胰岛在调节葡萄糖水平方面的整体功能。此外，对于需要胰岛素治疗的患者,抑制胰高血糖素分泌可能是至关重要的考虑因素.
