关键词: anti-tumor oxidative stress selenium selenoprotein selenosis zebrafish

来  源:   DOI:10.1093/toxres/tfae062   PDF(Pubmed)

Abstract:
Selenium is an important and essential trace element in organisms, but its effects on organisms are also a \"double-edged sword\". Selenium deficiency or excess can endanger the health of humans and animals. In order to thoroughly understand the nutritional value and toxicity hazards of selenium, researchers have conducted many studies on the model animal zebrafish. However, there is a lack of induction and summary of relevant research on which selenium acts on zebrafish. This paper provides a review of the reported studies. Firstly, this article summarizes the benefits of selenium on zebrafish from three aspects: Promoting growth, Enhancing immune function and anti-tumor ability, Antagonizing some pollutants, such as mercury. Then, three aspects of selenium toxicity to zebrafish are introduced: nervous system and behavior, reproductive system and growth, and damage to some organs. This article also describes how different forms of selenium compounds have different effects on zebrafish health. Finally, prospects for future research directions are presented.
摘要:
硒是生物体内重要且必需的微量元素,但它对生物体的影响也是一把“双刃剑”。硒缺乏或过量会危害人类和动物的健康。为了深入了解硒的营养价值和毒性危害,研究人员对斑马鱼的模型动物进行了许多研究。然而,硒对斑马鱼作用的相关研究缺乏归纳和总结。本文对已报道的研究进行了综述。首先,本文从三个方面总结了硒对斑马鱼的好处:促进生长,增强免疫功能和抗肿瘤能力,对抗一些污染物,比如汞。然后,介绍了硒对斑马鱼毒性的三个方面:神经系统和行为,生殖系统和生长,和一些器官的损伤。本文还介绍了不同形式的硒化合物对斑马鱼健康的影响。最后,展望了未来的研究方向。
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