UNASSIGNED: Thirty-two rats were allocated into four groups (n=8). Group (I) was considered normal control. Acetic acid (AA) was injected intrarectally in groups (2-4). Group (2) was kept untreated. Group (3) was administered CTZ (20 mg/kg/day) for 7 days. Group (4) was administered LOR (10 mg/kg/day) for 7 days.
UNASSIGNED: AA showed severe macroscopic colonic lesions associated with increased ulcer number, area, and severity with significantly elevated PI3K, p-Akt, Nrf2, TNF-α, and IL-6 in colorectal tissue as compared to the normal control group. All the aforementioned indicators were greatly improved by CTZ and LOR therapy.
UNASSIGNED: This is the first study to elucidate the ameliorative effect of CTZ and LOR against AA-induced UC in rats. CTZ and LOR treatment mitigates UC via amelioration of the PI3K/p-Akt/Nrf2 pathway and proinflammatory cytokine release.
■将32只大鼠分成4组(n=8)。组(I)为正常对照。组(2-4)直肠内注射乙酸(AA)。组(2)保持未处理。组(3)施用CTZ(20mg/kg/天)7天。组(4)施用LOR(10mg/kg/天)7天。
■AA显示严重的宏观结肠病变与溃疡数量增加有关,area,严重程度与PI3K显著升高,p-Akt,Nrf2,TNF-α,与正常对照组相比,结直肠组织中的IL-6。CTZ和LOR治疗对上述各项指标均有较大改善。
■这是首次阐明CTZ和LOR对AA诱导的大鼠UC的改善作用的研究。CTZ和LOR治疗通过改善PI3K/p-Akt/Nrf2途径和促炎细胞因子释放减轻UC。