PDF(Pubmed)
Abstract：
BACKGROUND: Subacute adult-acquired hemichorea is a striking presentation with a broad differential, including ischemic, metabolic, and inflammatory causes.
METHODS: We encountered a 74-year-old woman with rapid onset of hemichorea and associated encephalopathy. Following a thorough workup without identification of clear imaging or laboratory abnormalities, we empirically treated with IVIg. Her hemichorea dramatically improved. Due to relapses of hemichorea, she required repeat immunotherapy with IVIg or high dose steroids followed by maintenance mycophenolate.
CONCLUSIONS: This case of seronegative autoimmune hemichorea highlights the importance of a high index of suspicion for an inflammatory etiology of chorea when other causes are ruled out and performing an immunotherapy trial.
METHODS: We encountered a 74-year-old woman with rapid onset of hemichorea and associated encephalopathy. Following a thorough workup without identification of clear imaging or laboratory abnormalities, we empirically treated with IVIg. Her hemichorea dramatically improved. Due to relapses of hemichorea, she required repeat immunotherapy with IVIg or high dose steroids followed by maintenance mycophenolate.
CONCLUSIONS: This case of seronegative autoimmune hemichorea highlights the importance of a high index of suspicion for an inflammatory etiology of chorea when other causes are ruled out and performing an immunotherapy trial.
摘要：
背景：亚急性成人获得性偏球症是一种引人注目的表现，具有广泛的差异，包括缺血,新陈代谢，和炎症原因。
方法：我们遇到了一名74岁女性，患有偏瘫和相关脑病。经过彻底的检查，没有明确的成像或实验室异常，我们用IVIg进行了经验性治疗。她的半球性大大改善了。由于半球虫病复发,她需要用IVIg或大剂量类固醇进行重复免疫治疗,然后维持霉酚酸酯.
结论：这个血清阴性自身免疫性偏瘫病例强调了在排除其他原因并进行免疫治疗试验时高度怀疑舞蹈症的炎症病因的重要性。
方法：我们遇到了一名74岁女性，患有偏瘫和相关脑病。经过彻底的检查，没有明确的成像或实验室异常，我们用IVIg进行了经验性治疗。她的半球性大大改善了。由于半球虫病复发,她需要用IVIg或大剂量类固醇进行重复免疫治疗,然后维持霉酚酸酯.
结论：这个血清阴性自身免疫性偏瘫病例强调了在排除其他原因并进行免疫治疗试验时高度怀疑舞蹈症的炎症病因的重要性。
