PDF(Pubmed)
Abstract：
Investigating ventricular diastolic properties is crucial for understanding the physiological cardiac functions in organisms and unraveling the pathological mechanisms of cardiovascular disorders. Ventricular stiffness, a fundamental parameter that defines ventricular diastolic functions in chordates, is typically analyzed using the end-diastolic pressure-volume relationship (EDPVR). However, comparing ventricular stiffness accurately across chambers of varying maximum volume capacities has been a long-standing challenge. As one of the solutions to this problem, we propose calculating a relative ventricular stiffness index by applying an exponential approximation formula to the EDPVR plot data of the relationship between ventricular pressure and values of normalized ventricular volume by the ventricular weight. This article reviews the potential, utility, and limitations of using normalized EDPVR analysis in recent studies. Herein, we measured and ranked ventricular stiffness in differently sized and shaped chambers using ex vivo ventricular pressure-volume analysis data from four animals: Wistar rats, red-eared slider turtles, masu salmon, and cherry salmon. Furthermore, we have discussed the mechanical effects of intracellular and extracellular viscoelastic components, Titin (Connectin) filaments, collagens, physiological sarcomere length, and other factors that govern ventricular stiffness. Our review provides insights into the comparison of ventricular stiffness in different-sized ventricles between heterologous and homologous species, including non-model organisms.
摘要：
研究心室舒张特性对于了解生物体的生理心脏功能和揭示心血管疾病的病理机制至关重要。心室僵硬度,定义脊索心室舒张功能的基本参数，通常使用舒张末期压力-容积关系(EDPVR)进行分析。然而,在不同最大容量的腔室之间准确比较心室刚度是一个长期存在的挑战.作为这个问题的解决方案之一，我们建议通过将指数近似公式应用于EDPVR图数据来计算相对心室硬度指数,该数据是心室压力与心室重量归一化心室容积值之间的关系.这篇文章回顾了潜在的，实用程序，以及在最近的研究中使用标准化EDPVR分析的局限性。在这里，我们使用来自四只动物的离体心室压力-容积分析数据对不同大小和形状的腔室中的心室僵硬度进行测量和排序：Wistar大鼠，红耳龟,马苏鲑鱼,樱桃鲑鱼此外，我们已经讨论了细胞内和细胞外粘弹性成分的力学效应，Titin(Connectin)灯丝,胶原蛋白，生理肌节长度，和其他控制心室僵硬的因素。我们的评论提供了有关异源和同源物种之间不同大小心室中心室僵硬度的比较的见解。包括非模型生物。
