Abstract：
Non-coding RNAs (ncRNAs) are an assorted collection of transcripts that are not translated into proteins. Since their discovery, ncRNAs have gained prominence as crucial regulators of various biological functions across diverse cell types and tissues, and their abnormal functioning has been implicated in disease. Notably, extensive research has focused on the relationship between microRNAs (miRNAs) and human cancers, although other types of ncRNAs, such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are also emerging as significant contributors to human disease. In this review, we provide a comprehensive summary of our current knowledge regarding the roles of miRNAs, lncRNAs, and circRNAs in cancer and other major human diseases, particularly cancer, cardiovascular, neurological, and infectious diseases. Moreover, we discuss the potential utilization of ncRNAs as disease biomarkers and as targets for therapeutic interventions.
摘要：
非编码RNA(ncRNA)是不翻译成蛋白质的各种转录物的集合。自从他们发现,ncRNAs作为跨不同细胞类型和组织的各种生物学功能的关键调节因子，它们的异常功能与疾病有关。值得注意的是,广泛的研究集中在microRNAs（miRNAs）与人类癌症之间的关系，尽管其他类型的ncRNAs，例如长链非编码RNA（lncRNA）和环状RNA（circRNA），也正在成为人类疾病的重要贡献者。在这次审查中,我们提供了我们目前关于miRNA作用的知识的全面总结，lncRNAs,和circRNAs在癌症和其他主要人类疾病中，特别是癌症，心血管,神经学,和传染病。此外，我们讨论了ncRNAs作为疾病生物标志物和治疗干预靶点的潜在用途。
