Abstract：
Urinary tract infections (UTIs) are among the most common bacterial infections, posing significant public health challenges due to increasing antimicrobial resistance (AMR). This study aims to assess the prevalence, demographic characteristics, microbial profile, and antimicrobial resistance patterns in Indian patients with UTIs admitted to intensive care unit. A total of 154 patients with positive UTIs were included in this cross-sectional study. The prevalence data including demographics, microbial isolates, and antimicrobial susceptibility patterns were collected. Additionally, risk factors for multidrug resistance uropathogens were assessed using multivariate analyses. The patient cohort had diverse demographic, with a slight male predominance of 52.6% (n = 81). The most common comorbidities were hypertension 59.1% (n = 91) and diabetes mellitus 54.5% (n = 84). The microbial profile was dominated by gram-negative bacteria, particularly Escherichia coli 26.62% (n = 41) and Klebsiella pneumoniae 17.53% (n = 27). The predominant gram-positive and fungal isolate was Enterococcus faecium 7.14% (n = 11) and Candida spp. 18.83% (n = 29), respectively. Substantial resistance was noted against common antimicrobials, with variations across different pathogens. Gram-negative bacteria, particularly Escherichia coli and Klebsiella pneumoniae, exhibited high MDR rates, emphasizing the challenge of antimicrobial resistance. Multivariate logistic regression identified age groups 50-65 and over 65, and prolonged catheterization as significant risk factors for MDR infections. A significantly high resistance rate among pathogens emphasizes the need for judicious antimicrobial use. Our findings emphasize the necessity of ongoing surveillance and tailored interventions based on local pathogen prevalence and antibiogram data to effectively address the threat of AMR threat for better management of UTI management in ICU settings.
摘要：
尿路感染（UTI）是最常见的细菌感染，由于抗菌素耐药性（AMR）的增加，构成了重大的公共卫生挑战。这项研究旨在评估患病率，人口特征，微生物概况,以及重症监护病房的印度尿路感染患者的抗菌素耐药模式。共有154名尿路感染阳性的患者被纳入这项横断面研究。患病率数据包括人口统计数据，微生物分离，并收集抗菌药物敏感性模式。此外,使用多变量分析评估了多药耐药尿路病原体的危险因素.患者队列有不同的人口统计学，男性占52.6％（n=81）。最常见的合并症是高血压59.1%(n=91)和糖尿病54.5%(n=84)。微生物分布以革兰氏阴性菌为主,尤其是大肠埃希菌26.62%(n=41)和肺炎克雷伯菌17.53%(n=27)。主要的革兰氏阳性和真菌分离物是屎肠球菌7.14％（n=11）和念珠菌。18.83%（n=29），分别。对常见的抗菌素有明显的耐药性，不同病原体之间的差异。革兰氏阴性菌,特别是大肠杆菌和肺炎克雷伯菌，表现出很高的MDR率，强调抗菌素耐药性的挑战。多变量逻辑回归将50-65岁及65岁以上的年龄组和延长的导管插入术确定为MDR感染的重要危险因素。病原体中显著高的耐药率强调了明智使用抗微生物剂的必要性。我们的研究结果强调了基于当地病原体患病率和抗菌谱数据的持续监测和量身定制的干预措施的必要性，以有效地应对AMR威胁的威胁，从而更好地管理ICU环境中的UTI管理。
