Abstract：
OBJECTIVE: To assess whether oculoplastic surgeries can be performed without any topical and systemic antibiotics, in a \"100% antibiotic free\" fashion.
METHODS: We conducted a multicenter retrospective study between November 2017 and December 2022. Patients who underwent an oculoplastic procedure were screened. Patients who received preoperative or postoperative systemic antibiotics were excluded. Intraoperative IV antibiotics were allowed. Patients were divided into two groups: those who were treated with local antibiotics ointments (LATB group) and those who were treated without local antibiotics ointments (LATB free group) postoperatively. The primary outcome was the incidence of surgical site infections (SSI). The relationship between the use of local antibiotics and the occurrence of SSI was assessed using Fisher\'s exact test. The alpha risk was set to 5% and two-tailed tests were used.
RESULTS: Among the 947 procedures included, 617 were included in the LATB group and 330 in the LATB free group. 853 and 80 procedures were classified Altemeier class 1 (clean) and class 2 (clean-contaminated) surgeries, respectively. Overall, 310 (32.73%) procedures were performed without any systemic nor topical antibiotics (100% antibiotic free fashion). SSI occured in four (4/617; 0.65%) and five (5/330; 1.52%) procedures in the LATB and LATB free group respectively, without any statistical difference between the groups (p = 0.290). A subgroup analysis was carried out by excluding the procedures performed under prophylactic intraoperative intravenous antibiotics and did not reveal any statistical difference between the two groups (p = 0.144). All SSI patients were treated with systemic antibiotics with favorable outcomes. Postoperative wound dehiscence was the only risk factor associated with postoperative SSI (p = 0.002).
CONCLUSIONS: This study suggests that performing a \"100% antibiotic free\" oculoplastic surgery without systemic and topical antibiotics is reasonable in Altemeier class 1 and class 2 procedures.
METHODS: We conducted a multicenter retrospective study between November 2017 and December 2022. Patients who underwent an oculoplastic procedure were screened. Patients who received preoperative or postoperative systemic antibiotics were excluded. Intraoperative IV antibiotics were allowed. Patients were divided into two groups: those who were treated with local antibiotics ointments (LATB group) and those who were treated without local antibiotics ointments (LATB free group) postoperatively. The primary outcome was the incidence of surgical site infections (SSI). The relationship between the use of local antibiotics and the occurrence of SSI was assessed using Fisher\'s exact test. The alpha risk was set to 5% and two-tailed tests were used.
RESULTS: Among the 947 procedures included, 617 were included in the LATB group and 330 in the LATB free group. 853 and 80 procedures were classified Altemeier class 1 (clean) and class 2 (clean-contaminated) surgeries, respectively. Overall, 310 (32.73%) procedures were performed without any systemic nor topical antibiotics (100% antibiotic free fashion). SSI occured in four (4/617; 0.65%) and five (5/330; 1.52%) procedures in the LATB and LATB free group respectively, without any statistical difference between the groups (p = 0.290). A subgroup analysis was carried out by excluding the procedures performed under prophylactic intraoperative intravenous antibiotics and did not reveal any statistical difference between the two groups (p = 0.144). All SSI patients were treated with systemic antibiotics with favorable outcomes. Postoperative wound dehiscence was the only risk factor associated with postoperative SSI (p = 0.002).
CONCLUSIONS: This study suggests that performing a \"100% antibiotic free\" oculoplastic surgery without systemic and topical antibiotics is reasonable in Altemeier class 1 and class 2 procedures.
摘要：
目的：评估眼整形手术是否可以在没有任何局部和全身抗生素的情况下进行，以“100%无抗生素”的方式。
方法：我们在2017年11月至2022年12月之间进行了一项多中心回顾性研究。对接受眼眶手术的患者进行筛查。接受术前或术后全身抗生素的患者被排除在外。允许术中IV抗生素。患者分为两组：术后使用局部抗生素软膏治疗的患者（LATB组）和不使用局部抗生素软膏治疗的患者（LATB游离组）。主要结果是手术部位感染（SSI）的发生率。使用Fisher精确检验评估局部抗生素使用与SSI发生之间的关系。α风险设置为5%，并使用双尾测试。
结果：在包括的947个程序中，LATB组中包括617个，LATB游离组中包括330个。853和80个程序分为Altemeier1级（清洁）和2级（清洁污染）手术，分别。总的来说,在没有任何全身或局部抗生素(100%无抗生素的方式)的情况下进行310例(32.73%)手术。在LATB和LATB游离组中，SSI分别发生在四个（4/617;0.65％）和五个（5/330;1.52％）程序中。组间无统计学差异(p=0.290)。通过排除预防性术中静脉注射抗生素进行的手术进行亚组分析，两组之间没有任何统计学差异（p=0.144）。所有SSI患者均接受全身抗生素治疗，结果良好。术后伤口裂开是与术后SSI相关的唯一危险因素(p=0.002)。
结论：这项研究表明，在Altemeier1类和2类手术中，不使用全身和局部使用抗生素进行“100%无抗生素”眼整形手术是合理的。
方法：我们在2017年11月至2022年12月之间进行了一项多中心回顾性研究。对接受眼眶手术的患者进行筛查。接受术前或术后全身抗生素的患者被排除在外。允许术中IV抗生素。患者分为两组：术后使用局部抗生素软膏治疗的患者（LATB组）和不使用局部抗生素软膏治疗的患者（LATB游离组）。主要结果是手术部位感染（SSI）的发生率。使用Fisher精确检验评估局部抗生素使用与SSI发生之间的关系。α风险设置为5%，并使用双尾测试。
结果：在包括的947个程序中，LATB组中包括617个，LATB游离组中包括330个。853和80个程序分为Altemeier1级（清洁）和2级（清洁污染）手术，分别。总的来说,在没有任何全身或局部抗生素(100%无抗生素的方式)的情况下进行310例(32.73%)手术。在LATB和LATB游离组中，SSI分别发生在四个（4/617;0.65％）和五个（5/330;1.52％）程序中。组间无统计学差异(p=0.290)。通过排除预防性术中静脉注射抗生素进行的手术进行亚组分析，两组之间没有任何统计学差异（p=0.144）。所有SSI患者均接受全身抗生素治疗，结果良好。术后伤口裂开是与术后SSI相关的唯一危险因素(p=0.002)。
结论：这项研究表明，在Altemeier1类和2类手术中，不使用全身和局部使用抗生素进行“100%无抗生素”眼整形手术是合理的。
