Abstract：
Acne, a highly prevalent skin disease, can be particularly bothersome for patients of Asian background because of its impact on self-confidence and social interactions. In addition to active acne lesions, some patients may develop sequelae such as scarring, macular/postinflammatory hyperpigmentation, or erythema. The tendency of Asian skin to develop sequelae because of its increased susceptibility to irritation, cultural preferences for lighter skin phototypes, and differences in skincare regimens may all contribute to the increased burden of acne. Moreover, many Asia-Pacific countries do not have their own guidelines for acne management, and those that do often have no schedule in place for regular updates. In this article, we provide a critical review of the published guidance for the management of acne and its sequelae in the Asia-Pacific region, identifying gaps in current recommendations that could be addressed to enhance standards of acne care in Asia-Pacific countries. Along with highlighting the importance of a comprehensive skincare regimen to increase treatment efficacy and adherence, we discuss topical retinoids and retinoid combination options in the acne armamentarium that may be beneficial for sequelae prevention and management, such as adapalene 0.3% ± benzoyl peroxide 2.5%, tretinoin 0.05%, tazarotene 0.1%, and trifarotene 0.005%. In particular, trifarotene 0.005% has been observed to significantly reduce acne scar counts in a Phase 4 study. The recent data highlight the need to establish up-to-date guidance for acne and acne sequelae management in Asia-Pacific countries to provide optimal care to Asian patients.
摘要：
痤疮,一种非常普遍的皮肤病，对于亚洲背景的患者来说尤其麻烦，因为它对自信和社交互动的影响。除了活跃的痤疮病变，一些患者可能会出现后遗症，如疤痕，黄斑/炎症后色素沉着，或者红斑.亚洲皮肤由于其对刺激的敏感性增加而出现后遗症的趋势，对浅色皮肤照型的文化偏好，护肤方案的差异都可能导致痤疮负担的增加。此外，许多亚太国家没有自己的痤疮管理指南，而那些经常没有定期更新的时间表。在这篇文章中,我们对已发布的亚太地区痤疮及其后遗症管理指南进行了严格审查，确定当前建议中的差距，可以解决这些差距，以提高亚太国家的痤疮护理标准。除了强调全面护肤方案的重要性，以提高治疗效果和依从性，我们讨论了局部类维生素A和类维生素A组合的选择，在痤疮军械库，可能有利于后遗症的预防和管理，如阿达帕林0.3%±过氧化苯甲酰2.5%，维甲酸0.05%，他扎罗汀0.1%,和三法罗汀0.005%。特别是,在4期研究中，已观察到0.005％的trifarotene可显着减少痤疮疤痕计数。最近的数据突出表明，需要为亚太国家的痤疮和痤疮后遗症管理建立最新指南，以便为亚洲患者提供最佳护理。
