Mesh : Child Humans Levamisole / adverse effects Nephrotic Syndrome / drug therapy Prednisolone Glucocorticoids Recurrence

来  源:   DOI:10.1016/j.kint.2024.01.030

Abstract:
In the current issue of Kidney International, Sinha et al. present data from an open-label, noninferior, randomized controlled trial comparing 12-months of alternate-day prednisolone, given daily during infection, versus levamisole, in children with frequently relapsing or steroid-dependent nephrotic syndrome. This study suggests that both of these strategies are efficacious and safe. Results of this study should redefine the role of levamisole in future guidelines, and a call for global availability of levamisole should be advocated.
摘要:
在本期国际肾脏杂志上,Sinhaetal.从开放标签提供数据,非劣质,比较12个月隔日泼尼松龙的随机对照试验,在感染期间每天给予,与左旋咪唑相比,在经常复发或类固醇依赖性肾病综合征的儿童中。这项研究表明,这两种策略都是有效和安全的。这项研究的结果应该重新定义左旋咪唑在未来指南中的作用,并呼吁在全球范围内使用左旋咪唑。
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