METHODS: We searched Medline, PsycInfo, Embase and Web of Science from inception to July 2023. Seventeen prospective cohort studies with a total of 16061 women were included in the review, and risk of bias was assessed using the Quality in Prognosis Studies tool (QUIPS). Seven papers with a total of 9141 participants were included in meta-analyses, using random effects models and pooled odds ratios (OR) calculated for depressive symptoms and diagnoses.
RESULTS: Perimenopausal women were found to be at a significantly higher risk for depressive symptoms and diagnoses, compared to premenopausal women (OR = 1.40; 95 % CI: 1.21; 1.61, p < .001). We did not find a significantly increased risk for depressive symptoms or diagnoses in post-menopausal, compared to pre-menopausal women.
CONCLUSIONS: Studies used different criteria to classify the menopausal stages and different measures for depression, which may have contributed to the heterogeneity seen in some models. We were unable to include a model that compared peri to post-menopause, due to a lack of longitudinal studies comparing the two stages.
CONCLUSIONS: The risk of depression in perimenopause, shown in an ethnically diverse sample; highlights the clinical need for screening and support in this potentially vulnerable group.
方法:我们搜索了Medline,PsycInfo,Embase和WebofScience从成立到2023年7月。共有15,893名女性的17项前瞻性队列研究被纳入审查。使用预后研究质量工具(QUIPS)评估偏倚风险.共有11,965名参与者的七篇论文被纳入荟萃分析,使用随机效应模型和汇总优势比(OR)计算抑郁症状和诊断.
结果:发现围绝经期妇女患抑郁症状和诊断的风险明显更高,与绝经前女性相比(OR=1.40;95%CI:1.21;1.61,p<.001)。我们没有发现绝经后抑郁症状或诊断的风险显着增加,与绝经前妇女相比。
结论:研究使用不同的标准来分类更年期和不同的抑郁症措施,这可能导致了一些模型中看到的异质性。我们无法包含将围绝经期与绝经后进行比较的模型,由于缺乏比较这两个阶段的纵向研究。
结论:围绝经期抑郁症的风险,在不同种族的样本中显示;强调了在这个潜在弱势群体中筛查和支持的临床需求。