Abstract：
BACKGROUND: For many women, menopause transition can be a period of emotional and physical changes, with different menopausal stages associated with varied risk for depressive symptoms and diagnosis. This review aimed to conduct a systematic review and meta-analyses to provide an estimate for the risk of developing a) clinical depression and b) depressive symptoms at different menopausal stages.
METHODS: We searched Medline, PsycInfo, Embase and Web of Science from inception to July 2023. Seventeen prospective cohort studies with a total of 16061 women were included in the review, and risk of bias was assessed using the Quality in Prognosis Studies tool (QUIPS). Seven papers with a total of 9141 participants were included in meta-analyses, using random effects models and pooled odds ratios (OR) calculated for depressive symptoms and diagnoses.
RESULTS: Perimenopausal women were found to be at a significantly higher risk for depressive symptoms and diagnoses, compared to premenopausal women (OR = 1.40; 95 % CI: 1.21; 1.61, p < .001). We did not find a significantly increased risk for depressive symptoms or diagnoses in post-menopausal, compared to pre-menopausal women.
CONCLUSIONS: Studies used different criteria to classify the menopausal stages and different measures for depression, which may have contributed to the heterogeneity seen in some models. We were unable to include a model that compared peri to post-menopause, due to a lack of longitudinal studies comparing the two stages.
CONCLUSIONS: The risk of depression in perimenopause, shown in an ethnically diverse sample; highlights the clinical need for screening and support in this potentially vulnerable group.
METHODS: We searched Medline, PsycInfo, Embase and Web of Science from inception to July 2023. Seventeen prospective cohort studies with a total of 16061 women were included in the review, and risk of bias was assessed using the Quality in Prognosis Studies tool (QUIPS). Seven papers with a total of 9141 participants were included in meta-analyses, using random effects models and pooled odds ratios (OR) calculated for depressive symptoms and diagnoses.
RESULTS: Perimenopausal women were found to be at a significantly higher risk for depressive symptoms and diagnoses, compared to premenopausal women (OR = 1.40; 95 % CI: 1.21; 1.61, p < .001). We did not find a significantly increased risk for depressive symptoms or diagnoses in post-menopausal, compared to pre-menopausal women.
CONCLUSIONS: Studies used different criteria to classify the menopausal stages and different measures for depression, which may have contributed to the heterogeneity seen in some models. We were unable to include a model that compared peri to post-menopause, due to a lack of longitudinal studies comparing the two stages.
CONCLUSIONS: The risk of depression in perimenopause, shown in an ethnically diverse sample; highlights the clinical need for screening and support in this potentially vulnerable group.
摘要：
背景：对于许多女性来说，更年期过渡可能是一段情绪和身体变化的时期，不同的绝经阶段与抑郁症状和诊断的不同风险相关。这篇综述旨在进行系统综述和荟萃分析，以估计在不同的更年期发生a）临床抑郁症和b）抑郁症状的风险。
方法：我们搜索了Medline，PsycInfo,Embase和WebofScience从成立到2023年7月。共有15,893名女性的17项前瞻性队列研究被纳入审查。使用预后研究质量工具(QUIPS)评估偏倚风险.共有11,965名参与者的七篇论文被纳入荟萃分析，使用随机效应模型和汇总优势比(OR)计算抑郁症状和诊断.
结果：发现围绝经期妇女患抑郁症状和诊断的风险明显更高，与绝经前女性相比（OR=1.40；95%CI：1.21；1.61，p<.001）。我们没有发现绝经后抑郁症状或诊断的风险显着增加，与绝经前妇女相比。
结论：研究使用不同的标准来分类更年期和不同的抑郁症措施，这可能导致了一些模型中看到的异质性。我们无法包含将围绝经期与绝经后进行比较的模型，由于缺乏比较这两个阶段的纵向研究。
结论：围绝经期抑郁症的风险，在不同种族的样本中显示；强调了在这个潜在弱势群体中筛查和支持的临床需求。
方法：我们搜索了Medline，PsycInfo,Embase和WebofScience从成立到2023年7月。共有15,893名女性的17项前瞻性队列研究被纳入审查。使用预后研究质量工具(QUIPS)评估偏倚风险.共有11,965名参与者的七篇论文被纳入荟萃分析，使用随机效应模型和汇总优势比(OR)计算抑郁症状和诊断.
结果：发现围绝经期妇女患抑郁症状和诊断的风险明显更高，与绝经前女性相比（OR=1.40；95%CI：1.21；1.61，p<.001）。我们没有发现绝经后抑郁症状或诊断的风险显着增加，与绝经前妇女相比。
结论：研究使用不同的标准来分类更年期和不同的抑郁症措施，这可能导致了一些模型中看到的异质性。我们无法包含将围绝经期与绝经后进行比较的模型，由于缺乏比较这两个阶段的纵向研究。
结论：围绝经期抑郁症的风险，在不同种族的样本中显示；强调了在这个潜在弱势群体中筛查和支持的临床需求。
