肌球蛋白抑制剂逆转基因型不同的小儿 iPSC 心肌细胞中的肥厚型心肌病 , 以反映变异校正。
关键词: CRISPR gene editing MYBPC3 MYH7 cardiomyocytes hypertrophic cardiomyopathy induced pluripotent stem cells metoprolol myosin ATPase inhibitor pediatric verapamil
Mesh : Humans Induced Pluripotent Stem Cells / metabolism drug effects Cardiomyopathy, Hypertrophic / genetics drug therapy pathology metabolism Cardiac Myosins / genetics metabolism Child Myocytes, Cardiac / metabolism drug effects pathology Myosin Heavy Chains / genetics metabolism Carrier Proteins / genetics metabolism Genotype Myosins / metabolism genetics Male Female Sarcomeres / metabolism genetics
来 源:
DOI:10.1016/j.xcrm.2024.101520
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