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Abstract：
BACKGROUND: This study aimed to analyze the trends of Parkinson\'s disease (PD) mortality rates among Chinese residents from 2004 to 2021, provide evidence for the formulation of PD prevention and control strategies to improve the quality of life among PD residents.
METHODS: Demographic and sociological data such as gender, urban or rural residency and age were obtained from the National Cause of Death Surveillance Dataset from 2004 to 2021. We then analyzed the trends of PD mortality rates by Joinpoint regression.
RESULTS: The PD mortality and standardized mortality rates in China showed an overall increasing trend during 2004-2021 (average annual percentage change [AAPC] = 7.14%, AAPCASMR=3.21%, P < 0.001). The mortality and standardized mortality rate in male (AAPC = 7.65%, AAPCASMR=3.18%, P < 0.001) were higher than that of female (AAPC = 7.03%, AAPCASMR=3.09%, P < 0.001). The PD standardized mortality rates of urban (AAPC = 5.13%, AAPCASMR=1.76%, P < 0.001) and rural (AAPC = 8.40%, AAPCASMR=4.29%, P < 0.001) residents both increased gradually. In the age analysis, the mortality rate increased with age. And the mortality rates of those aged > 85 years was the highest. Considering gender, female aged > 85 years had the fastest mortality trend (annual percentage change [APC] = 5.69%, P < 0.001). Considering urban/rural, rural aged 80-84 years had the fastest mortality trend (APC = 6.68%, P < 0.001).
CONCLUSIONS: The mortality rate of PD among Chinese residents increased from 2004 to 2021. Male sex, urban residence and age > 85 years were risk factors for PD-related death and should be the primary focus for PD prevention.
METHODS: Demographic and sociological data such as gender, urban or rural residency and age were obtained from the National Cause of Death Surveillance Dataset from 2004 to 2021. We then analyzed the trends of PD mortality rates by Joinpoint regression.
RESULTS: The PD mortality and standardized mortality rates in China showed an overall increasing trend during 2004-2021 (average annual percentage change [AAPC] = 7.14%, AAPCASMR=3.21%, P < 0.001). The mortality and standardized mortality rate in male (AAPC = 7.65%, AAPCASMR=3.18%, P < 0.001) were higher than that of female (AAPC = 7.03%, AAPCASMR=3.09%, P < 0.001). The PD standardized mortality rates of urban (AAPC = 5.13%, AAPCASMR=1.76%, P < 0.001) and rural (AAPC = 8.40%, AAPCASMR=4.29%, P < 0.001) residents both increased gradually. In the age analysis, the mortality rate increased with age. And the mortality rates of those aged > 85 years was the highest. Considering gender, female aged > 85 years had the fastest mortality trend (annual percentage change [APC] = 5.69%, P < 0.001). Considering urban/rural, rural aged 80-84 years had the fastest mortality trend (APC = 6.68%, P < 0.001).
CONCLUSIONS: The mortality rate of PD among Chinese residents increased from 2004 to 2021. Male sex, urban residence and age > 85 years were risk factors for PD-related death and should be the primary focus for PD prevention.
摘要：
背景：本研究旨在分析2004-2021年中国居民帕金森病（PD）死亡率的变化趋势，为制定PD防治策略提供依据，以提高PD居民的生活质量。
方法：人口统计学和社会学数据，如性别，从2004年至2021年的国家死因监测数据集中获得了城市或农村的居住权和年龄。然后，我们通过Joinpoint回归分析了PD死亡率的趋势。
结果：中国的PD死亡率和标准化死亡率在2004-2021年期间呈现总体上升趋势（平均每年百分比变化[AAPC]=7.14％，AAPCAMR=3.21%，P<0.001)。男性死亡率和标准化死亡率(AAPC=7.65%，AAPCAMR=3.18%，P<0.001)高于女性(AAPC=7.03%,AAPCAMR=3.09%，P<0.001)。城市PD标准化死亡率(AAPC=5.13%，AAPCAMR=1.76%，P<0.001)和农村(AAPC=8.40%，AAPCAMR=4.29%，P<0.001)居民均逐渐增加。在年龄分析中,死亡率随年龄增长而增加。85岁以上人群的死亡率最高。考虑到性别,年龄>85岁的女性死亡率趋势最快(年变化百分比[APC]=5.69%，P<0.001)。考虑到城市/农村，80-84岁的农村人口死亡率趋势最快(APC=6.68%，P<0.001)。
结论：从2004年到2021年，中国居民PD死亡率上升。男性,城市居住地和年龄>85岁是PD相关死亡的危险因素,应作为PD预防的主要重点.
方法：人口统计学和社会学数据，如性别，从2004年至2021年的国家死因监测数据集中获得了城市或农村的居住权和年龄。然后，我们通过Joinpoint回归分析了PD死亡率的趋势。
结果：中国的PD死亡率和标准化死亡率在2004-2021年期间呈现总体上升趋势（平均每年百分比变化[AAPC]=7.14％，AAPCAMR=3.21%，P<0.001)。男性死亡率和标准化死亡率(AAPC=7.65%，AAPCAMR=3.18%，P<0.001)高于女性(AAPC=7.03%,AAPCAMR=3.09%，P<0.001)。城市PD标准化死亡率(AAPC=5.13%，AAPCAMR=1.76%，P<0.001)和农村(AAPC=8.40%，AAPCAMR=4.29%，P<0.001)居民均逐渐增加。在年龄分析中,死亡率随年龄增长而增加。85岁以上人群的死亡率最高。考虑到性别,年龄>85岁的女性死亡率趋势最快(年变化百分比[APC]=5.69%，P<0.001)。考虑到城市/农村，80-84岁的农村人口死亡率趋势最快(APC=6.68%，P<0.001)。
结论：从2004年到2021年，中国居民PD死亡率上升。男性,城市居住地和年龄>85岁是PD相关死亡的危险因素,应作为PD预防的主要重点.
