Abstract：
A 6-year-old spayed female Scottish Fold cat presented with lethargy and anorexia. A complete blood cell count indicated severe anemia and mild thrombocytopenia. Examination of peripheral blood smears revealed marked changes in the erythroid lineage, including the presence of basophilic stippling and Howell-Jolly bodies as well as an increase in nucleated erythrocytes, polychromatophils, ovalocytes, and schistocytes. Additionally, some erythrocytes contained a ring or figure-eight shaped structure known as a Cabot ring, which were especially observed in polychromatophilic erythrocytes. Hemolytic diseases (Mycoplasma infection and IMHA) were diagnostically excluded, and the cat was treated through prednisolone administration, whole blood transfusion, and administration of vitamins (K2 and B12); however, the anemia progressively worsened. Cabot rings were observed until Day 22 and subsequently disappeared as the number of nucleated RBCs increased, and the erythrocyte lineage shifted to immature population. On Day 42, peripheral blood examination revealed further left shifting and appearance of many rubriblasts. The patient died at home on Day 43. Necropsy revealed neoplastic cells infiltrating the bone marrow and other organs, which were immunopositive to CD71 which is an erythroid lineage marker. In humans, Cabot rings have been observed in megaloblastic anemia, lead poisoning, myelodysplastic syndrome, and myelofibrosis; further, they are thought to be related to stressed bone marrow and dyserythropoiesis. This is the first case report of a cat with Cabot rings, which are suggestive of defects in erythroid lineage production.
摘要：
一只6岁的雌性苏格兰折叠猫，表现出嗜睡和厌食症。全血细胞计数提示严重贫血和轻度血小板减少。外周血涂片检查显示红系谱系有明显变化，包括嗜碱性点画和Howell-Jolly体的存在以及有核红细胞的增加，多嗜铬细胞,卵母细胞,和分裂细胞。此外,一些红细胞含有环状或8字形结构，称为卡博特环，特别是在多色性红细胞中观察到。溶血病（支原体感染和IMHA）被诊断排除，猫通过泼尼松龙治疗，全血输血,和维生素（K2和B12）的管理;然而，贫血逐渐恶化。观察到Cabot环直到第22天，随后随着有核红细胞数量的增加而消失，红细胞谱系转移到未成熟群体。在第42天，外周血检查显示进一步向左移动，并出现了许多成核细胞。患者于第43天在家死亡。尸检显示肿瘤细胞浸润骨髓和其他器官，对作为红系谱系标记的CD71免疫阳性。在人类中,在巨幼细胞性贫血中观察到卡博特环，铅中毒,骨髓增生异常综合征,和骨髓纤维化；此外，它们被认为与应激性骨髓和红细胞生成异常有关。这是首例有卡博特环的猫的病例报告,这暗示了红系谱系生产的缺陷。
