关键词: Development Drug repurposing Liver disorders Molecular signals New drugs

Mesh : Drug Repositioning / methods Humans Liver Diseases / drug therapy Computational Biology / methods Drug Discovery / methods

来  源:   DOI:10.1016/j.lfs.2024.122642

Abstract:
Drug repurposing involves the investigation of existing drugs for new indications. It offers a great opportunity to quickly identify a new drug candidate at a lower cost than novel discovery and development. Despite the importance and potential role of drug repurposing, there is no specific definition that healthcare providers and the World Health Organization credit. Unfortunately, many similar and interchangeable concepts are being used in the literature, making it difficult to collect and analyze uniform data on repurposed drugs. This research was conducted based on understanding general criteria for drug repurposing, concentrating on liver diseases. Many drugs have been investigated for their effect on liver diseases even though they were originally approved (or on their way to being approved) for other diseases. Some of the hypotheses for drug repurposing were first captured from the literature and then processed further to test the hypothesis. Recently, with the revolution in bioinformatics techniques, scientists have started to use drug libraries and computer systems that can analyze hundreds of drugs to give a short list of candidates to be analyzed pharmacologically. However, this study revealed that drug repurposing is a potential aid that may help deal with liver diseases. It provides available or under-investigated drugs that could help treat hepatitis, liver cirrhosis, Wilson disease, liver cancer, and fatty liver. However, many further studies are needed to ensure the efficacy of these drugs on a large scale.
摘要:
药物再利用涉及对现有药物的新适应症的调查。它提供了一个很好的机会,可以以比新的发现和开发更低的成本快速鉴定新药候选物。尽管药物再利用的重要性和潜在作用,没有明确的定义,医疗保健提供者和世界卫生组织的信用。不幸的是,文献中使用了许多相似和可互换的概念,这使得很难收集和分析再利用药物的统一数据。这项研究是基于了解药物再利用的一般标准,专注于肝脏疾病。已经研究了许多药物对肝脏疾病的影响,即使它们最初被批准(或正在被批准)用于其他疾病。首先从文献中捕获了一些用于药物再利用的假设,然后对其进行进一步处理以检验该假设。最近,随着生物信息学技术的革命,科学家们已经开始使用药物库和计算机系统,可以分析数百种药物,以给出一个简短的候选药物列表进行药理学分析。然而,这项研究表明,药物再利用是一种可能有助于治疗肝脏疾病的潜在辅助手段。它提供了可以帮助治疗肝炎的可用药物或研究不足的药物,肝硬化,威尔逊病,肝癌,和脂肪肝。然而,需要许多进一步的研究来确保这些药物的大规模疗效。
公众号