Abstract：
Chlamydia trachomatis (CT) is a sexually transmitted infection that can lead to adverse reproductive health outcomes. CT prevalence estimates are primarily derived from screening using nucleic acid amplification tests (NAATs). However, screening guidelines in the United States only include particular subpopulations, and NAATs only detect current infections. In contrast, seroassays identify past CT infections which are important for understanding the public health impacts of CT, including pelvic inflammatory disease and tubal factor infertility. Older seroassays have been plagued by low sensitivity and specificity and have not been validated using a consistent reference measure, making it challenging to compare studies, define the epidemiology of CT and determine the effectiveness of control programs. Newer seroassays have better performance characteristics. This narrative review summarizes the \"state of the science\" for CT seroassays that have been applied in epidemiologic studies and provides practical considerations for interpreting the literature and employing seroassays in future research.
摘要：
沙眼衣原体（CT）是一种性传播感染，可导致不良的生殖健康结果。CT患病率估计主要来自使用核酸扩增测试（NAAT）的筛查。然而,美国的筛查指南仅包括特定的亚群，NAAT只能检测当前的感染。相比之下,血清分析确定过去的CT感染，这对于了解CT对公共卫生的影响很重要。包括盆腔炎和输卵管因素不孕症。较老的血清测定一直受到低灵敏度和特异性的困扰，并且尚未使用一致的参考措施进行验证。使比较研究具有挑战性，定义CT的流行病学并确定控制计划的有效性。较新的血清测定具有更好的性能特征。这篇叙述性综述总结了已在流行病学研究中应用的CT血清测定的“科学状态”，并为解释文献和在未来研究中使用血清测定提供了实际考虑。
