PDF(Pubmed)
Abstract：
Human lectins are integral to maintaining microbial homeostasis on the skin, in the blood, and at mucosal barriers. These proteins can recognize microbial glycans and inform the host about its microbial status. In accordance with their roles, their production can vary with tissue type. They also can have unique structural and biochemical properties, and they can influence microbial colonization at sites proximal and distal to their tissue of origin. In line with their classification as innate immune proteins, soluble lectins have long been studied in the context of acute infectious disease, but only recently have we begun to appreciate their roles in maintaining commensal microbial communities (i.e., the human microbiota). This review provides an overview of soluble lectins that operate at host-microbe interfaces, their glycan recognition properties, and their roles in physiological and pathological mechanisms.
摘要：
人类凝集素是维持皮肤微生物稳态的组成部分，在血液中，和粘膜屏障。这些蛋白质可以识别微生物聚糖并告知宿主其微生物状态。根据他们的角色,它们的生产可以随组织类型而变化。它们还可以具有独特的结构和生化特性，它们可以影响微生物在其起源组织的近端和远端定植。根据它们作为先天免疫蛋白的分类，可溶性凝集素长期以来一直在急性传染病的背景下进行研究，但直到最近，我们才开始意识到它们在维持共生微生物群落中的作用(即，人类微生物群)。这篇综述概述了在宿主-微生物界面上运行的可溶性凝集素，它们的聚糖识别特性，以及它们在生理和病理机制中的作用。
