Abstract：
The majority of problematic conditions resulting from dental implant treatment are inflammatory in character, but certain isolated occurrences of primary oral squamous cell carcinoma (OSCC) have been discovered in the area of implants. The goal of this study was to examine whether there is a link between dental implants and the development of OSCC in patients who have a history of a potentially malignant lesion (PML) or malignancy. Using the keywords \"carcinoma\" AND \"dental implants,\" a search was conducted in the MEDLINE (PubMed), National Center for Biotechnology Information, and Google Scholar databases for case reports and case series in which OSCC was discovered as a primary cancer in the region of dental implants. An initial search identified 260 articles, 247 of which were excluded based on study inclusion or exclusion criteria, leaving 13 articles chosen for inclusion and a total of 30 patients who developed primary oral cancer surrounding osseointegrated titanium-based dental implants. In the studies included in the present review, 22 (73%) of 30 patients with peri-implant cancer had a history of PML or carcinoma. There is no statistical evidence of a direct association between dental implants and OSCC in patients with a history of a PML or malignant lesion. There have been some case reports of OSCC in the region of dental implants in patients with a history of a PML or malignant lesion, but further studies are needed to prove a definitive relationship.
摘要：
牙科种植治疗导致的大多数问题都是炎症，但是在植入物领域发现了某些孤立的原发性口腔鳞状细胞癌（OSCC）。这项研究的目的是检查有潜在恶性病变（PML）或恶性肿瘤病史的患者的牙种植体与OSCC的发展之间是否存在联系。使用关键词\"癌\"和\"种植牙,\“在MEDLINE（PubMed）中进行了搜索，国家生物技术信息中心,和GoogleScholar数据库提供病例报告和病例系列，其中OSCC被发现是牙科植入物区域的原发性癌症。最初的搜索确定了260篇文章，根据研究纳入或排除标准，其中247例被排除，选择纳入13篇文章，共有30名患者发生骨整合钛基牙种植体周围的原发性口腔癌。在本综述中包括的研究中，30例植入物周围癌患者中有22例（73％）有PML或癌史。在有PML或恶性病变病史的患者中，没有统计学证据表明牙种植体与OSCC之间存在直接关联。在有PML或恶性病变病史的患者中，在牙种植体区域有一些OSCC的病例报告，但是还需要进一步的研究来证明这种明确的关系。
