Abstract：
OBJECTIVE: To investigate the clinical efficacy of dapoxetine combined with transcutaneous neuromuscular electrical stimulation (TNES) in the treatment of primary premature ejaculation.
METHODS: A total of 60 patients who met the diagnostic criteria for primary premature ejaculation were selected as study subjects and randomly divided into a dapoxetine group (control group) and a dapoxetine combined with percutaneous neuromuscular electrical stimulation group (observation group).30 patients in each group were treated for 4 weeks. Intravaginal ejaculatory latency time (IELT), the score of Premature Ejaculation Diagnostic Tool (PEDT), sympathetic skin response located in the penis (PSSR), Patient Health Questionnaire (PHQ-9), and Generalized Anxiety Disorder Questionnaire (GAD-7) before and after treatment were recorded in the two groups. Before and after treatment, the difference in observed indexes in the two groups and the comparison of effective rates between the two groups were analyzed.
RESULTS: The latency of IELT and PSSR was prolonged and the PEDT score was decreased in both the observation group and the control group, the difference was statistically significant (P<0.01). Compared with the control group, the observation group had statistically significant differences in extending IELT and PSSR latency and reducing PEDT score (P<0.05). The effective rates of the observation group and control group were 90% and 63.33%, respectively, and the difference was statistically significant (P<0.05). There was no significant difference in the improvement of depression and anxiety levels between the two groups (P> 0.05).
CONCLUSIONS: Dapoxetine combined with TNES has a better clinical effect than dapoxetine alone in the treatment of primary premature ejaculation, and can be used as an effective option for clinical treatment of primary premature ejaculation.
METHODS: A total of 60 patients who met the diagnostic criteria for primary premature ejaculation were selected as study subjects and randomly divided into a dapoxetine group (control group) and a dapoxetine combined with percutaneous neuromuscular electrical stimulation group (observation group).30 patients in each group were treated for 4 weeks. Intravaginal ejaculatory latency time (IELT), the score of Premature Ejaculation Diagnostic Tool (PEDT), sympathetic skin response located in the penis (PSSR), Patient Health Questionnaire (PHQ-9), and Generalized Anxiety Disorder Questionnaire (GAD-7) before and after treatment were recorded in the two groups. Before and after treatment, the difference in observed indexes in the two groups and the comparison of effective rates between the two groups were analyzed.
RESULTS: The latency of IELT and PSSR was prolonged and the PEDT score was decreased in both the observation group and the control group, the difference was statistically significant (P<0.01). Compared with the control group, the observation group had statistically significant differences in extending IELT and PSSR latency and reducing PEDT score (P<0.05). The effective rates of the observation group and control group were 90% and 63.33%, respectively, and the difference was statistically significant (P<0.05). There was no significant difference in the improvement of depression and anxiety levels between the two groups (P> 0.05).
CONCLUSIONS: Dapoxetine combined with TNES has a better clinical effect than dapoxetine alone in the treatment of primary premature ejaculation, and can be used as an effective option for clinical treatment of primary premature ejaculation.
摘要：
目的：探讨达泊西汀联合经皮神经肌肉电刺激(TNES)治疗原发性早泄的临床疗效。
方法：选择符合原发性早泄诊断标准的60例患者作为研究对象，随机分为达泊西汀组（对照组）和达泊西汀联合经皮神经肌肉电刺激组（观察组），每组30例，疗程4周。阴道内射精潜伏期（IELT），早泄诊断工具（PEDT）的评分，位于阴茎（PSSR）的交感神经皮肤反应，患者健康问卷（PHQ-9），记录两组患者治疗前后的广泛性焦虑障碍问卷(GAD-7)。治疗前后,分析两组观察指标的差异及两组有效率的比较。
结果：观察组和对照组IELT和PSSR潜伏期延长，PEDT评分降低，差异有统计学意义(P<0.01)。与对照组相比,观察组在延长IELT和PSSR潜伏期、降低PEDT评分方面差异有统计学意义(P<0.05)。观察组和对照组的有效率分别为90%和63.33%。分别,差异有统计学意义(P<0.05)。两组患者的抑郁、焦虑改善水平比较,差异无统计学意义(P>0.05)。
结论：达泊西汀联合TNES治疗原发性早泄的临床疗效优于单用达泊西汀。可作为临床治疗原发性早泄的有效选择。
方法：选择符合原发性早泄诊断标准的60例患者作为研究对象，随机分为达泊西汀组（对照组）和达泊西汀联合经皮神经肌肉电刺激组（观察组），每组30例，疗程4周。阴道内射精潜伏期（IELT），早泄诊断工具（PEDT）的评分，位于阴茎（PSSR）的交感神经皮肤反应，患者健康问卷（PHQ-9），记录两组患者治疗前后的广泛性焦虑障碍问卷(GAD-7)。治疗前后,分析两组观察指标的差异及两组有效率的比较。
结果：观察组和对照组IELT和PSSR潜伏期延长，PEDT评分降低，差异有统计学意义(P<0.01)。与对照组相比,观察组在延长IELT和PSSR潜伏期、降低PEDT评分方面差异有统计学意义(P<0.05)。观察组和对照组的有效率分别为90%和63.33%。分别,差异有统计学意义(P<0.05)。两组患者的抑郁、焦虑改善水平比较,差异无统计学意义(P>0.05)。
结论：达泊西汀联合TNES治疗原发性早泄的临床疗效优于单用达泊西汀。可作为临床治疗原发性早泄的有效选择。
