RESULTS: cTnl (cardiac troponin I) was measured in 32 968 participants of the fourth wave of the population-based cohort HUNT4 (Trøndelag Health Study) without a history of cardiovascular disease. An additional longitudinal analysis included participants from HUNT4 with BP measurements from HUNT3 (n=18 681). Associations between BP variables and cTnI concentrations were assessed by linear and logistic regression analyses. The median cTnI concentration was 1.6 ng/L (25th-75th percentiles, 0.6-3.1 ng/L), median age was 52 years (39.1-65.6 years), and 57% were female subjects. Cross-sectionally, only systolic BP categories ≥130 mm Hg associated with higher cTnI concentrations, compared with a reference systolic BP of <110 mm Hg. All categories of diastolic BP and pulse pressure were positively associated with higher cTnI concentrations when diastolic BP 70 to 79 mm Hg and pulse pressure <40 mm Hg were used as references, respectively. When comparing systolic BP, diastolic BP, and pulse pressure as continuous variables, cross-sectionally, pulse pressure most strongly associated with cTnI concentrations (P for all comparisons <0.001), whereas longitudinally, change in diastolic BP was most strongly associated with cTnI concentrations (P for all comparisons <0.05).
CONCLUSIONS: Subjects with high pulse pressure and longitudinal increase in diastolic BP are at higher risk for subclinical myocardial injury.
结果:cTnl(心肌肌钙蛋白I)是在没有心血管疾病史的基于人群的队列HUNT4(Trøndelag健康研究)的第四波中的32968名参与者中测量的。另一项纵向分析包括来自HUNT4的参与者和来自HUNT3的BP测量(n=18681)。通过线性和逻辑回归分析评估BP变量与cTnI浓度之间的关联。cTnI浓度中位数为1.6ng/L(第25-75百分位数,0.6-3.1ng/L),中位年龄为52岁(39.1-65.6岁),57%是女性受试者。跨领域,只有收缩压类别≥130mmHg与更高的cTnI浓度相关,与参考收缩压<110mmHg相比。当使用舒张压70至79mmHg和脉压<40mmHg作为参考时,所有类别的舒张压和脉压均与较高的cTnI浓度呈正相关。分别。比较收缩压时,舒张压,和脉压作为连续变量,横截面,脉压与cTnI浓度密切相关(所有比较的P<0.001),而纵向,舒张压的变化与cTnI浓度密切相关(所有比较P<0.05).
结论:高脉压和舒张压纵向升高的受试者发生亚临床心肌损伤的风险较高。