PDF(Pubmed)
Abstract：
The complex evolution of genetic alterations in cancer that occurs in vivo is a selective process involving numerous factors and mechanisms. Chemotherapeutic agents that prevent the growth and spread of cancer cells induce selective pressure, leading to rapid artificial selection of resistant subclones. This rapid evolution is possible because antineoplastic drugs promote alterations in tumor‑cell metabolism, thus creating a bottleneck event. The few resistant cells that survive in this new environment obtain differential reproductive success that enables them to pass down the newly selected resistant gene pool. The present review aims to summarize key findings of tumor evolution, epithelial‑mesenchymal transition and resistance to cetuximab therapy in head and neck squamous cell carcinoma.
摘要：
体内发生的癌症遗传改变的复杂进化是涉及多种因素和机制的选择性过程。阻止癌细胞生长和扩散的化学治疗剂诱导选择性压力，导致快速人工选择抗性亚克隆。这种快速进化是可能的，因为抗肿瘤药物促进肿瘤细胞代谢的改变，从而产生瓶颈事件。在这种新环境中存活的少数抗性细胞获得差异繁殖成功，使它们能够传递新选择的抗性基因库。本综述旨在总结肿瘤演变的关键发现，头颈部鳞状细胞癌的上皮间质转化和西妥昔单抗治疗耐药。
