PDF(Pubmed)
Abstract：
Preeclampsia (PE) is one of the most common complications of pregnancy and polycystic ovary syndrome (PCOS) is a prevalent metabolic and endocrinopathy disorder in women of reproductive age. Identifying the shared genetic signatures and molecular mechanisms between PCOS and PE was the objective of this study. The intersections of WGCNA module genes, PPI module genes, and PPI hub genes revealed that 8 immunity-related genes might be shared causative genes of PE and PCOS. Further, qRT-PCR results showed that TSIX/miR-223-3p/DDX58 might play a crucial role in immune dysregulation in PE and PCOS and Spearman rank correlation analysis results illustrated the potential of DDX58 as a novel diagnostic and therapeutic target for PE and PCOS. Our study demonstrated a common disease pathway model TSIX/miR-223-3p/DDX58, illustrating that immune dysregulation may be a possible mechanism of PE and PCOS, and revealed that DDX58 might be a novel predictive target for PE and PCOS.
摘要：
子痫前期（PE）是妊娠最常见的并发症之一，多囊卵巢综合征（PCOS）是育龄妇女普遍存在的代谢和内分泌疾病。确定PCOS和PE之间的共同遗传特征和分子机制是本研究的目的。WGCNA模块基因的交叉，PPI模块基因，PPIhub基因显示，8个免疫相关基因可能是PE和PCOS的共同致病基因。Further,qRT-PCR结果显示，TSIX/miR-223-3p/DDX58可能在PE和PCOS的免疫失调中起关键作用，Spearman秩相关分析结果说明了DDX58作为PE和PCOS新的诊断和治疗靶点的潜力。我们的研究证明了常见的疾病通路模型TSIX/miR-223-3p/DDX58，说明免疫失调可能是PE和PCOS的可能机制。并揭示DDX58可能是PE和PCOS的新预测靶标。
