PDF(Pubmed)
Abstract：
UNASSIGNED: Our aim was to explore the disease burden caused by gallbladder and biliary tract cancer globally, regionally, and nationally, by age and sex.
UNASSIGNED: The absolute number of cases and age-standardized rates (ASR) of incidence, prevalence, mortality, and disability-adjusted life years (DALYs) due to gallbladder and biliary tract cancer were extracted from the Global Burden of Disease (GBD) Study 2019. We estimated the trends in disease burden by calculating the percentage change in the absolute number of cases and the estimated annual percentage change (EAPC) in ASR, by social development index (SDI), region, nation, sex, and age.
UNASSIGNED: From 1990 to 2019, the number of incident cases, prevalent cases, deaths, and DALYs worldwide significantly increased by 1.85-fold, 1.92-fold, 1.82-fold, and 1.68-fold, respectively. However, the age-standardized rates of incidence, prevalence, mortality, and DALYs tend to decrease globally over time. Nevertheless, heterogeneous disease burden patterns exist between geographic regions due to different geographical risk factors, distinct epidemiologically predominant gallbladder and biliary tract cancer subtypes, and potential genetic predispositions or ethnicity. Additionally, socioeconomic status mediates the regional variation in disease burden, with increasing SDI or HDI scores associated with downward trends in the age-standardized rates of incidence, prevalence, mortality, and DALYs. Older individuals and females are at higher risk of gallbladder and biliary tract cancer, but the increasing burden of early-onset gallbladder and biliary tract cancer is a cause for concern, especially for those living in lower SDI areas and males. High BMI is the primary risk factors underlying gallbladder and biliary tract cancer, accounted for 15.2% of deaths and 15.7% DALYs globally in 2019.
UNASSIGNED: Our study comprehensively elucidated the distribution and dynamic trends of gallbladder and biliary tract cancer burden over the past three decades, from multiple dimensions. These findings emphasize the importance of promoting a healthy lifestyle as a population-level cancer prevention strategy and tailoring cancer control actions based on localized risk factors and the epidemic profiles of gallbladder and biliary tract cancer by anatomical subtype.
UNASSIGNED: The absolute number of cases and age-standardized rates (ASR) of incidence, prevalence, mortality, and disability-adjusted life years (DALYs) due to gallbladder and biliary tract cancer were extracted from the Global Burden of Disease (GBD) Study 2019. We estimated the trends in disease burden by calculating the percentage change in the absolute number of cases and the estimated annual percentage change (EAPC) in ASR, by social development index (SDI), region, nation, sex, and age.
UNASSIGNED: From 1990 to 2019, the number of incident cases, prevalent cases, deaths, and DALYs worldwide significantly increased by 1.85-fold, 1.92-fold, 1.82-fold, and 1.68-fold, respectively. However, the age-standardized rates of incidence, prevalence, mortality, and DALYs tend to decrease globally over time. Nevertheless, heterogeneous disease burden patterns exist between geographic regions due to different geographical risk factors, distinct epidemiologically predominant gallbladder and biliary tract cancer subtypes, and potential genetic predispositions or ethnicity. Additionally, socioeconomic status mediates the regional variation in disease burden, with increasing SDI or HDI scores associated with downward trends in the age-standardized rates of incidence, prevalence, mortality, and DALYs. Older individuals and females are at higher risk of gallbladder and biliary tract cancer, but the increasing burden of early-onset gallbladder and biliary tract cancer is a cause for concern, especially for those living in lower SDI areas and males. High BMI is the primary risk factors underlying gallbladder and biliary tract cancer, accounted for 15.2% of deaths and 15.7% DALYs globally in 2019.
UNASSIGNED: Our study comprehensively elucidated the distribution and dynamic trends of gallbladder and biliary tract cancer burden over the past three decades, from multiple dimensions. These findings emphasize the importance of promoting a healthy lifestyle as a population-level cancer prevention strategy and tailoring cancer control actions based on localized risk factors and the epidemic profiles of gallbladder and biliary tract cancer by anatomical subtype.
摘要：
■我们的目标是探索全球胆囊癌和胆道癌引起的疾病负担，区域性,在全国范围内,按年龄和性别。
■发病率的绝对病例数和年龄标准化率（ASR），患病率,死亡率,从2019年全球疾病负担（GBD）研究中提取了因胆囊癌和胆道癌导致的残疾调整寿命年（DALYs）。我们通过计算ASR的绝对病例数的百分比变化和估计的年度百分比变化（EAPC）来估计疾病负担的趋势，按社会发展指数(SDI)计算，区域,nation,性别,和年龄。
■从1990年到2019年，事故案例数量，普遍的情况下，死亡,全球DALYs显着增加了1.85倍，1.92倍，1.82倍，和1.68倍，分别。然而,年龄标准化的发病率，患病率,死亡率,随着时间的推移，DALY在全球范围内往往会减少。然而，由于不同的地理风险因素，不同地理区域之间存在异质性疾病负担模式，独特的流行病学优势胆囊和胆道癌亚型，和潜在的遗传倾向或种族。此外,社会经济地位调节疾病负担的区域变化，随着SDI或HDI评分的增加与年龄标准化发病率的下降趋势相关，患病率,死亡率,和DALYs。老年人和女性患胆囊癌和胆道癌的风险更高，但是，早发性胆囊癌和胆道癌的负担日益增加，特别是对于那些生活在较低的SDI地区和男性。高BMI是胆囊癌和胆道癌的主要危险因素，2019年占全球死亡人数的15.2%和DALY的15.7%。
■我们的研究全面阐明了过去三十年来胆囊和胆道癌症负担的分布和动态趋势，从多个维度。这些发现强调了促进健康生活方式作为人群癌症预防策略的重要性，并根据局部风险因素以及胆囊和胆道癌的解剖学亚型流行特征来定制癌症控制措施。
■发病率的绝对病例数和年龄标准化率（ASR），患病率,死亡率,从2019年全球疾病负担（GBD）研究中提取了因胆囊癌和胆道癌导致的残疾调整寿命年（DALYs）。我们通过计算ASR的绝对病例数的百分比变化和估计的年度百分比变化（EAPC）来估计疾病负担的趋势，按社会发展指数(SDI)计算，区域,nation,性别,和年龄。
■从1990年到2019年，事故案例数量，普遍的情况下，死亡,全球DALYs显着增加了1.85倍，1.92倍，1.82倍，和1.68倍，分别。然而,年龄标准化的发病率，患病率,死亡率,随着时间的推移，DALY在全球范围内往往会减少。然而，由于不同的地理风险因素，不同地理区域之间存在异质性疾病负担模式，独特的流行病学优势胆囊和胆道癌亚型，和潜在的遗传倾向或种族。此外,社会经济地位调节疾病负担的区域变化，随着SDI或HDI评分的增加与年龄标准化发病率的下降趋势相关，患病率,死亡率,和DALYs。老年人和女性患胆囊癌和胆道癌的风险更高，但是，早发性胆囊癌和胆道癌的负担日益增加，特别是对于那些生活在较低的SDI地区和男性。高BMI是胆囊癌和胆道癌的主要危险因素，2019年占全球死亡人数的15.2%和DALY的15.7%。
■我们的研究全面阐明了过去三十年来胆囊和胆道癌症负担的分布和动态趋势，从多个维度。这些发现强调了促进健康生活方式作为人群癌症预防策略的重要性，并根据局部风险因素以及胆囊和胆道癌的解剖学亚型流行特征来定制癌症控制措施。
