PDF(Pubmed)
Abstract：
This case report documents the first instance of Penicillin-Susceptible Methicillin-Resistant Staphylococcus aureus (PS-MRSA) in a Chinese psychiatric hospital. The strain was isolated from a patient with Alzheimer\'s disease who had a lower respiratory tract infection. Clinical and laboratory analyses, including mass spectrometry, antibiotic susceptibility testing, and whole-genome sequencing, confirmed the PS-MRSA strain. In this case, we systematically introduce the clinical symptoms, laboratory findings, and treatment responses associated with this PS-MRSA strain. This discovery offers a new perspective on our understanding of resistance mechanisms and expands our considerations for existing antibiotic treatments. It may fill a gap in the classification of MRSA strains, enhance the spectrum of MRSA resistance, and complete the therapeutic strategies for MRSA.
摘要：
该病例报告记录了中国精神病医院首例青霉素敏感耐甲氧西林金黄色葡萄球菌（PS-MRSA）。该菌株是从患有下呼吸道感染的阿尔茨海默病患者中分离出来的。临床和实验室分析，包括质谱,抗生素药敏试验,和全基因组测序，确认PS-MRSA菌株。在这种情况下,我们系统地介绍了临床症状，实验室发现,和与该PS-MRSA菌株相关的治疗反应。这一发现为我们对抗性机制的理解提供了新的视角，并扩展了我们对现有抗生素治疗的考虑。它可能填补了MRSA菌株分类的空白，增强MRSA抗性谱，完成MRSA的治疗策略。
