关键词: aqueous humor blood diabetes glucose monitoring noncontact optical

Mesh : Humans Blood Glucose Aqueous Humor Prospective Studies Glucose Diabetes Mellitus Optical Devices

来  源:   DOI:10.1117/1.JBO.29.4.047001   PDF(Pubmed)

Abstract:
UNASSIGNED: Monitoring blood glucose levels is crucial for individuals with diabetes. Noninvasive methods for measuring serum glucose levels have been explored to aid in blood glucose control for diabetes management.
UNASSIGNED: We introduced a noncontact optical glucometer (NCGM) for measuring glucose levels in the aqueous humor of the human eye. We also investigated the correlation between glucose levels in the NCGM and the aqueous humor, blood samples, and self-monitoring blood glucose devices.
UNASSIGNED: The optical system used in this study measured both the near-infrared absorption and polarized rotatory distribution of glucose molecules in the human aqueous humor. This prospective study\'s outcomes were eye aqueous glucose level, preoperative blood glucose level, intraoperative blood glucose level, and NCGM reading of patients in a single center in Taiwan.
UNASSIGNED: The NCGM\'s measurements showed a strong correlation with blood glucose levels (intra-class correlation [ICC]: 0.95 to 0.98) and aqueous humor glucose levels (ICC: 0.76), indicating its ability to noninvasively measure blood glucose levels in human subjects.
UNASSIGNED: This NCGM may offer a convenient, pain-free, and rapid tool for measuring blood glucose levels in diabetic patients. The device could represent a significant advancement in noncontact hybrid optical glucose measurement systems.
摘要:
监测血糖水平对糖尿病患者至关重要。已经探索了用于测量血清葡萄糖水平的非侵入性方法,以帮助控制血糖以进行糖尿病管理。
我们引入了一种非接触式光学血糖仪(NCGM),用于测量人眼房水中的葡萄糖水平。我们还调查了NCGM和房水葡萄糖水平之间的相关性,血液样本,和自我监测血糖设备。
本研究中使用的光学系统测量了人房水中葡萄糖分子的近红外吸收和偏振旋转分布。这项前瞻性研究的结果是眼水葡萄糖水平,术前血糖水平,术中血糖水平,和NCGM对台湾单一中心患者的读数。
NCGM的测量显示与血糖水平(类内相关性[ICC]:0.95至0.98)和房水葡萄糖水平(ICC:0.76)有很强的相关性,表明其非侵入性测量人类受试者的血糖水平的能力。
此NCGM可能会提供方便,无痛,和快速测量糖尿病患者血糖水平的工具。该装置可以代表非接触混合光学葡萄糖测量系统的显著进步。
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