PDF(Pubmed)
Abstract：
BACKGROUND: Metformin is an insulin sensitizer that is widely used for the treatment of insulin resistance in polycystic ovary syndrome patients. However, metformin can cause gastrointestinal side effects.
OBJECTIVE: This study showed that the effects of quercetin are comparable to those of metformin. Therefore, this study aimed to systematically evaluate the efficacy of quercetin in treating PCOS.
METHODS: The present systematic search of the Chinese National Knowledge Infrastructure (CNKI), Wanfang Data Information Site, Chinese Scientific Journals Database (VIP), SinoMed, Web of Science, and PubMed databases was performed from inception until February 2024. The methodological quality was then assessed by SYRCLE\'s risk of bias tool, and the data were analyzed by RevMan 5.3 software.
RESULTS: Ten studies were included in the meta-analysis. Compared with those in the model group, quercetin in the PCOS group had significant effects on reducing fasting insulin serum (FIS) levels (P = 0.0004), fasting blood glucose (FBG) levels (P = 0.01), HOMA-IR levels (P < 0.00001), cholesterol levels (P < 0.0001), triglyceride levels (P = 0.001), testosterone (T) levels (P < 0.00001), luteinizing hormone (LH) levels (P = 0.0003), the luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio (P = 0.01), vascular endothelial growth factor (VEGF) levels (P < 0.00001), malondialdehyde (MDA) levels (P = 0.03), superoxide dismutase (SOD) levels (P = 0.01) and GLUT4 mRNA expression (P < 0.00001).
CONCLUSIONS: This meta-analysis suggested that quercetin has positive effects on PCOS treatment. Quercetin can systematically reduce insulin, blood glucose, cholesterol, and triglyceride levels in metabolic pathways. In the endocrine pathway, quercetin can regulate the function of the pituitary-ovarian axis, reduce testosterone and luteinizing hormone (LH) levels, and lower the ratio of LH to follicle-stimulating hormone (FSH). Quercetin can regulate the expression of the GLUT4 gene and has antioxidative effects at the molecular level.
OBJECTIVE: This study showed that the effects of quercetin are comparable to those of metformin. Therefore, this study aimed to systematically evaluate the efficacy of quercetin in treating PCOS.
METHODS: The present systematic search of the Chinese National Knowledge Infrastructure (CNKI), Wanfang Data Information Site, Chinese Scientific Journals Database (VIP), SinoMed, Web of Science, and PubMed databases was performed from inception until February 2024. The methodological quality was then assessed by SYRCLE\'s risk of bias tool, and the data were analyzed by RevMan 5.3 software.
RESULTS: Ten studies were included in the meta-analysis. Compared with those in the model group, quercetin in the PCOS group had significant effects on reducing fasting insulin serum (FIS) levels (P = 0.0004), fasting blood glucose (FBG) levels (P = 0.01), HOMA-IR levels (P < 0.00001), cholesterol levels (P < 0.0001), triglyceride levels (P = 0.001), testosterone (T) levels (P < 0.00001), luteinizing hormone (LH) levels (P = 0.0003), the luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio (P = 0.01), vascular endothelial growth factor (VEGF) levels (P < 0.00001), malondialdehyde (MDA) levels (P = 0.03), superoxide dismutase (SOD) levels (P = 0.01) and GLUT4 mRNA expression (P < 0.00001).
CONCLUSIONS: This meta-analysis suggested that quercetin has positive effects on PCOS treatment. Quercetin can systematically reduce insulin, blood glucose, cholesterol, and triglyceride levels in metabolic pathways. In the endocrine pathway, quercetin can regulate the function of the pituitary-ovarian axis, reduce testosterone and luteinizing hormone (LH) levels, and lower the ratio of LH to follicle-stimulating hormone (FSH). Quercetin can regulate the expression of the GLUT4 gene and has antioxidative effects at the molecular level.
摘要：
背景：二甲双胍是一种胰岛素增敏剂，广泛用于治疗多囊卵巢综合征患者的胰岛素抵抗。然而,二甲双胍可引起胃肠道副作用。
目的：本研究表明槲皮素的作用与二甲双胍相当。因此,本研究旨在系统评价槲皮素治疗PCOS的疗效。
方法：当前对中国国家知识基础设施的系统搜索(CNKI)，万方数据信息网站，中国科技期刊数据库(VIP),SinoMed,WebofScience,和PubMed数据库从开始到2024年2月进行。然后通过SYRCLE的偏倚风险工具评估方法学质量，数据采用RevMan5.3软件进行分析。
结果：10项研究纳入荟萃分析。与模型组相比，PCOS组有显著降低空腹胰岛素(FIS)水平的作用(P=0.0004),空腹血糖(FBG)水平(P=0.01),HOMA-IR水平（P<0.00001），胆固醇水平（P<0.0001），甘油三酯水平（P=0.001），睾酮（T）水平（P<0.00001），黄体生成素（LH）水平（P=0.0003），黄体生成素/卵泡刺激素(LH/FSH)比值(P=0.01),血管内皮生长因子(VEGF)水平(P<0.00001),丙二醛（MDA）水平（P=0.03），超氧化物歧化酶(SOD)水平(P=0.01)和GLUT4mRNA表达(P<0.00001)。
结论：这项荟萃分析提示槲皮素对PCOS治疗有积极作用。槲皮素可以系统地减少胰岛素，血糖，胆固醇,和代谢途径中的甘油三酯水平。在内分泌通路中,槲皮素可以调节垂体-卵巢轴的功能，降低睾酮和黄体生成素（LH）水平，并降低LH与卵泡刺激素（FSH）的比例。槲皮素可以调节GLUT4基因的表达，并在分子水平上具有抗氧化作用。
目的：本研究表明槲皮素的作用与二甲双胍相当。因此,本研究旨在系统评价槲皮素治疗PCOS的疗效。
方法：当前对中国国家知识基础设施的系统搜索(CNKI)，万方数据信息网站，中国科技期刊数据库(VIP),SinoMed,WebofScience,和PubMed数据库从开始到2024年2月进行。然后通过SYRCLE的偏倚风险工具评估方法学质量，数据采用RevMan5.3软件进行分析。
结果：10项研究纳入荟萃分析。与模型组相比，PCOS组有显著降低空腹胰岛素(FIS)水平的作用(P=0.0004),空腹血糖(FBG)水平(P=0.01),HOMA-IR水平（P<0.00001），胆固醇水平（P<0.0001），甘油三酯水平（P=0.001），睾酮（T）水平（P<0.00001），黄体生成素（LH）水平（P=0.0003），黄体生成素/卵泡刺激素(LH/FSH)比值(P=0.01),血管内皮生长因子(VEGF)水平(P<0.00001),丙二醛（MDA）水平（P=0.03），超氧化物歧化酶(SOD)水平(P=0.01)和GLUT4mRNA表达(P<0.00001)。
结论：这项荟萃分析提示槲皮素对PCOS治疗有积极作用。槲皮素可以系统地减少胰岛素，血糖，胆固醇,和代谢途径中的甘油三酯水平。在内分泌通路中,槲皮素可以调节垂体-卵巢轴的功能，降低睾酮和黄体生成素（LH）水平，并降低LH与卵泡刺激素（FSH）的比例。槲皮素可以调节GLUT4基因的表达，并在分子水平上具有抗氧化作用。
