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Abstract：
Abnormal uterine bleeding (AUB) during the menopausal transition results in reproductive endocrine disorders and both physiological and pathological changes, substantially impacting women\'s health. This study aimed to investigate the factors influencing AUB in perimenopausal women. Between April 2021 and June 2022, 120 perimenopausal women with AUB in the menopausal transition, diagnosed and treated at the Gynaecology Department of Kunming Tongren Hospital, were included in the case group. Concurrently, women undergoing routine health examinations at the same hospital were randomly selected as the control group. Univariate and multivariate logistic regression analyses identified factors related to AUB. The univariate analysis revealed significant associations (P < 0.05) between AUB and several factors, including age, body mass index (BMI), age at menarche, gravidity, and intrauterine device (IUD) placement in perimenopausal women. The multivariate regression analysis indicated that the independent risk factors for AUB include benign endometrial lesions (odds ratio [OR] 5.243, 95% confidence interval [CI] 3.082-9.458, P < 0.001), endometrial thickness ≥ 10 mm (OR 1.573, 95% CI 0.984-3.287, P < 0.001), age ≥ 50 years (OR 2.045, 95% CI 1.035-4.762, P = 0.001), BMI ≥ 25 kg/m2 (OR 2.436, 95% CI 1.43-4.86, P = 0.002), and IUD placement (OR 2.458, 95% CI 1.253-4.406, P < 0.001). Abnormal uterine bleeding during the menopausal transition is associated with several factors, including age, BMI, and IUD placement, highlighting the importance of early screening for these risk factors in the diagnosis and treatment of AUB.
摘要：
绝经过渡期异常子宫出血（AUB）导致生殖内分泌紊乱和生理和病理变化，严重影响女性健康。本研究旨在探讨围绝经期妇女AUB的影响因素。2021年4月至2022年6月，120名处于更年期过渡期的围绝经期女性AUB，昆明同仁医院妇科诊治,包括在病例组中。同时,随机选择在同一医院接受常规健康检查的妇女作为对照组。单变量和多变量逻辑回归分析确定了与AUB相关的因素。单因素分析显示，AUB与几个因素之间存在显著关联(P<0.05)。包括年龄,体重指数（BMI），初潮年龄,妊娠,围绝经期妇女放置宫内节育器（IUD）。多因素回归分析显示AUB的独立危险因素包括子宫内膜良性病变(比值比[OR]5.243,95%置信区间[CI]3.082～9.458,P<0.001)。子宫内膜厚度≥10mm(OR1.573,95%CI0.984-3.287,P<0.001),年龄≥50岁（OR2.045，95%CI1.035-4.762，P=0.001），BMI≥25kg/m2（OR2.436，95%CI1.43-4.86，P=0.002），和宫内节育器放置（OR2.458，95%CI1.253-4.406，P<0.001）。绝经过渡期异常子宫出血与几个因素有关，包括年龄,BMI,和宫内节育器的放置，强调在AUB的诊断和治疗中早期筛查这些危险因素的重要性。
