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Abstract：
BACKGROUND: The glandular odontogenic cyst (GOC) is a benign developmental cyst of the jaws that is characterized by a high recurrence rate.
METHODS: A systematic review is presented of reported cases, case series, and retrospective studies of recurrent cases of glandular odontogenic cysts, to determine the overall and detailed demographic features with documentation of the specific histologic features of the initial presentation of each cyst. Searches of detailed databases were carried out to identify articles published in the English language from 1988 to 2023. The variables were demographics, patient symptoms, cyst location, radiographic features, histopathological findings, type of treatment, and minimum eight months of follow-up.
RESULTS: Eighteen cases were identified: with an equal gender presentation of 50% females and 50% males. The average age was 44.7. The mean size was 3.5 cm. The most common location was in the anterior mandible in 50% (n = 9) of cases, followed by the posterior mandible 27.8% (n = 5). Most patients were asymptomatic 55.6% (n = 10). The most common histologic features at first diagnosis were mucous cells in 88.9% (n = 16), variable thickness with 83.3% (n = 15), eosinophilic cuboidal cells 88.9% (n = 16), microcysts 83.3% (n = 15), and clear cells 77.8% (n = 14) cases.
CONCLUSIONS: GOC has an aggressive behavior. Evidence was not conclusive to link any single or combination of histologic features to recurrence, and the strongest correlation for recurrence was the type of treatment. Since this is an uncommon cyst, more cases are needed. Follow-up should continue for at least five years, because recurrences were higher between years 3 and 5.
METHODS: A systematic review is presented of reported cases, case series, and retrospective studies of recurrent cases of glandular odontogenic cysts, to determine the overall and detailed demographic features with documentation of the specific histologic features of the initial presentation of each cyst. Searches of detailed databases were carried out to identify articles published in the English language from 1988 to 2023. The variables were demographics, patient symptoms, cyst location, radiographic features, histopathological findings, type of treatment, and minimum eight months of follow-up.
RESULTS: Eighteen cases were identified: with an equal gender presentation of 50% females and 50% males. The average age was 44.7. The mean size was 3.5 cm. The most common location was in the anterior mandible in 50% (n = 9) of cases, followed by the posterior mandible 27.8% (n = 5). Most patients were asymptomatic 55.6% (n = 10). The most common histologic features at first diagnosis were mucous cells in 88.9% (n = 16), variable thickness with 83.3% (n = 15), eosinophilic cuboidal cells 88.9% (n = 16), microcysts 83.3% (n = 15), and clear cells 77.8% (n = 14) cases.
CONCLUSIONS: GOC has an aggressive behavior. Evidence was not conclusive to link any single or combination of histologic features to recurrence, and the strongest correlation for recurrence was the type of treatment. Since this is an uncommon cyst, more cases are needed. Follow-up should continue for at least five years, because recurrences were higher between years 3 and 5.
摘要：
背景：腺牙源性囊肿（GOC）是颌骨的良性发育性囊肿，其特征是复发率高。
方法：对报告的病例进行了系统评价，案例系列,和腺性牙源性囊肿复发病例的回顾性研究，通过记录每个囊肿初始表现的具体组织学特征来确定总体和详细的人口统计学特征。对详细的数据库进行了搜索，以识别1988年至2023年以英语发表的文章。变量是人口统计，患者症状,囊肿位置,射线照相特征，组织病理学发现,治疗类型,和至少8个月的随访。
结果：确认了18例病例：女性占50%，男性占50%。平均年龄为44.7岁。平均尺寸为3.5cm。在50％（n=9）的病例中，最常见的位置是下颌骨前部，其次是后下颌骨27.8%(n=5)。大多数患者无症状55.6％（n=10）。首次诊断时最常见的组织学特征是88.9％（n=16）的粘液细胞，可变厚度为83.3%(n=15)，嗜酸性粒细胞长方体88.9%(n=16),微小囊肿83.3%(n=15)，透明细胞占77.8%(n=14)。
结论：GOC具有攻击性行为。没有确凿的证据将任何单一或组合的组织学特征与复发联系起来，复发的相关性最强的是治疗类型。因为这是一个不常见的囊肿,需要更多的案例。后续行动应至少持续五年，因为3年和5年之间的复发较高。
方法：对报告的病例进行了系统评价，案例系列,和腺性牙源性囊肿复发病例的回顾性研究，通过记录每个囊肿初始表现的具体组织学特征来确定总体和详细的人口统计学特征。对详细的数据库进行了搜索，以识别1988年至2023年以英语发表的文章。变量是人口统计，患者症状,囊肿位置,射线照相特征，组织病理学发现,治疗类型,和至少8个月的随访。
结果：确认了18例病例：女性占50%，男性占50%。平均年龄为44.7岁。平均尺寸为3.5cm。在50％（n=9）的病例中，最常见的位置是下颌骨前部，其次是后下颌骨27.8%(n=5)。大多数患者无症状55.6％（n=10）。首次诊断时最常见的组织学特征是88.9％（n=16）的粘液细胞，可变厚度为83.3%(n=15)，嗜酸性粒细胞长方体88.9%(n=16),微小囊肿83.3%(n=15)，透明细胞占77.8%(n=14)。
结论：GOC具有攻击性行为。没有确凿的证据将任何单一或组合的组织学特征与复发联系起来，复发的相关性最强的是治疗类型。因为这是一个不常见的囊肿,需要更多的案例。后续行动应至少持续五年，因为3年和5年之间的复发较高。
