PDF(Pubmed)
Abstract：
Mild traumatic brain injury is theorized to cause widespread functional changes to the brain. Resting-state fMRI may be able to measure functional connectivity changes after traumatic brain injury, but resting-state fMRI studies are heterogeneous, using numerous techniques to study ROIs across various resting-state networks.
We systematically reviewed the literature to ascertain whether adult patients who have experienced mild traumatic brain injury show consistent functional connectivity changes on resting-state -fMRI, compared with healthy patients.
We used 5 databases (PubMed, EMBASE, Cochrane Central, Scopus, Web of Science).
Five databases (PubMed, EMBASE, Cochrane Central, Scopus, and Web of Science) were searched for research published since 2010. Search strategies used keywords of \"functional MR imaging\" and \"mild traumatic brain injury\" as well as related terms. All results were screened at the abstract and title levels by 4 reviewers according to predefined inclusion and exclusion criteria. For full-text inclusion, each study was evaluated independently by 2 reviewers, with discordant screening settled by consensus.
Data regarding article characteristics, cohort demographics, fMRI scan parameters, data analysis processing software, atlas used, data characteristics, and statistical analysis information were extracted.
Across 66 studies, 80 areas were analyzed 239 times for at least 1 time point, most commonly using independent component analysis. The most analyzed areas and networks were the whole brain, the default mode network, and the salience network. Reported functional connectivity changes varied, though there may be a slight trend toward decreased whole-brain functional connectivity within 1 month of traumatic brain injury and there may be differences based on the time since injury.
Studies of military, sports-related traumatic brain injury, and pediatric patients were excluded. Due to the high number of relevant studies and data heterogeneity, we could not be as granular in the analysis as we would have liked.
Reported functional connectivity changes varied, even within the same region and network, at least partially reflecting differences in technical parameters, preprocessing software, and analysis methods as well as probable differences in individual injury. There is a need for novel rs-fMRI techniques that better capture subject-specific functional connectivity changes.
We systematically reviewed the literature to ascertain whether adult patients who have experienced mild traumatic brain injury show consistent functional connectivity changes on resting-state -fMRI, compared with healthy patients.
We used 5 databases (PubMed, EMBASE, Cochrane Central, Scopus, Web of Science).
Five databases (PubMed, EMBASE, Cochrane Central, Scopus, and Web of Science) were searched for research published since 2010. Search strategies used keywords of \"functional MR imaging\" and \"mild traumatic brain injury\" as well as related terms. All results were screened at the abstract and title levels by 4 reviewers according to predefined inclusion and exclusion criteria. For full-text inclusion, each study was evaluated independently by 2 reviewers, with discordant screening settled by consensus.
Data regarding article characteristics, cohort demographics, fMRI scan parameters, data analysis processing software, atlas used, data characteristics, and statistical analysis information were extracted.
Across 66 studies, 80 areas were analyzed 239 times for at least 1 time point, most commonly using independent component analysis. The most analyzed areas and networks were the whole brain, the default mode network, and the salience network. Reported functional connectivity changes varied, though there may be a slight trend toward decreased whole-brain functional connectivity within 1 month of traumatic brain injury and there may be differences based on the time since injury.
Studies of military, sports-related traumatic brain injury, and pediatric patients were excluded. Due to the high number of relevant studies and data heterogeneity, we could not be as granular in the analysis as we would have liked.
Reported functional connectivity changes varied, even within the same region and network, at least partially reflecting differences in technical parameters, preprocessing software, and analysis methods as well as probable differences in individual injury. There is a need for novel rs-fMRI techniques that better capture subject-specific functional connectivity changes.
摘要：
背景：理论上认为轻度创伤性脑损伤会导致大脑广泛的功能改变。静息状态功能磁共振成像可能能够测量创伤性脑损伤后的功能连接变化，但是静息状态功能磁共振成像研究是异质的，使用多种技术来研究各种静息状态网络的ROI。
目的：我们系统回顾了文献，以确定经历轻度创伤性脑损伤的成年患者在静息状态-fMRI上是否表现出一致的功能连接变化，与健康患者相比。
方法：我们使用了5个数据库(PubMed，EMBASE,CochraneCentral,Scopus,WebofScience）。
方法：五个数据库(PubMed，EMBASE,CochraneCentral,Scopus,和WebofScience)搜索了自2010年以来发表的研究。搜索策略使用“功能性MR成像”和“轻度创伤性脑损伤”的关键词以及相关术语。根据预定义的纳入和排除标准，由4名审阅者在摘要和标题级别筛选所有结果。对于全文包含，每个研究由2名评审员独立评估，不和谐的筛查以协商一致的方式解决。
方法：有关文章特征的数据，队列人口统计，fMRI扫描参数，数据分析处理软件,使用的图集,数据特征，并提取统计分析信息。
结果：在66项研究中，80个区域分析239次，至少1个时间点，最常用的是独立成分分析。分析最多的区域和网络是整个大脑，默认模式网络，和显著性网络。报告的功能连接变化各不相同，尽管在创伤性脑损伤后的1个月内，全脑功能连通性可能有轻微下降的趋势，并且可能因受伤后的时间而异。
结论：军事研究，运动相关的创伤性脑损伤，儿科患者被排除在外.由于大量的相关研究和数据异质性，我们在分析中不可能像我们希望的那样精细。
结论：报告的功能连通性变化各不相同，即使在同一地区和网络内，至少部分反映了技术参数的差异，预处理软件,和分析方法以及个体伤害的可能差异。需要新的rs-fMRI技术,其更好地捕获受试者特异性功能连通性变化。
目的：我们系统回顾了文献，以确定经历轻度创伤性脑损伤的成年患者在静息状态-fMRI上是否表现出一致的功能连接变化，与健康患者相比。
方法：我们使用了5个数据库(PubMed，EMBASE,CochraneCentral,Scopus,WebofScience）。
方法：五个数据库(PubMed，EMBASE,CochraneCentral,Scopus,和WebofScience)搜索了自2010年以来发表的研究。搜索策略使用“功能性MR成像”和“轻度创伤性脑损伤”的关键词以及相关术语。根据预定义的纳入和排除标准，由4名审阅者在摘要和标题级别筛选所有结果。对于全文包含，每个研究由2名评审员独立评估，不和谐的筛查以协商一致的方式解决。
方法：有关文章特征的数据，队列人口统计，fMRI扫描参数，数据分析处理软件,使用的图集,数据特征，并提取统计分析信息。
结果：在66项研究中，80个区域分析239次，至少1个时间点，最常用的是独立成分分析。分析最多的区域和网络是整个大脑，默认模式网络，和显著性网络。报告的功能连接变化各不相同，尽管在创伤性脑损伤后的1个月内，全脑功能连通性可能有轻微下降的趋势，并且可能因受伤后的时间而异。
结论：军事研究，运动相关的创伤性脑损伤，儿科患者被排除在外.由于大量的相关研究和数据异质性，我们在分析中不可能像我们希望的那样精细。
结论：报告的功能连通性变化各不相同，即使在同一地区和网络内，至少部分反映了技术参数的差异，预处理软件,和分析方法以及个体伤害的可能差异。需要新的rs-fMRI技术,其更好地捕获受试者特异性功能连通性变化。
